Creg1 cellular repressor of E1A-stimulated genes 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Creg1provided by MGI
Official Full Name: cellular repressor of E1A-stimulated genes 1provided by MGI
Primary source: MGI:MGI:1344382
See related: Ensembl:ENSMUSG00000040713 AllianceGenome:MGI:1344382
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Creg
Summary: Acts upstream of or within regulation of transcription, DNA-templated. Part of transcription regulator complex. Is expressed in liver and ureter. Orthologous to human CREG1 (cellular repressor of E1A stimulated genes 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta adult (RPKM 225.0), liver adult (RPKM 174.7) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 H2.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (165591327..165602878)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (165763758..165775309)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CREG1 stimulates AMPK phosphorylation and glucose uptake in skeletal muscle cells.
Title: CREG1 stimulates AMPK phosphorylation and glucose uptake in skeletal muscle cells.
CREG ameliorates the phenotypic switching of cardiac fibroblasts after myocardial infarction via modulation of CDC42.
Title: CREG ameliorates the phenotypic switching of cardiac fibroblasts after myocardial infarction via modulation of CDC42.
Effects of CREG1 on Age-Associated Metabolic Phenotypes and Renal Senescence in Mice.
Title: Effects of CREG1 on Age-Associated Metabolic Phenotypes and Renal Senescence in Mice.
The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases.
Title: The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases.
findings demonstrate that CREG1 stimulates brown adipocyte formation and browning, ameliorating obesity and its related pathology in vivo.
Title: CREG1 stimulates brown adipocyte formation and ameliorates diet-induced obesity in mice.
effect of CREG1 on Ucp1 promoter activity was also stimulated by retinoic acid. These results strongly suggest that CREG1 plays an important role on the regulation of UCP1 expression and brown adipogenesis
Title: CREG1 promotes uncoupling protein 1 expression and brown adipogenesis in vitro.
Transplantation of CREG-modified embryonic stem cells exhibits a favorable survival pattern in infarcted hearts, which translates into a substantial preservation of cardiac function after acute myocardial infarction.
Title: Transplantation of CREG modified embryonic stem cells improves cardiac function after myocardial infarction in mice.
CREG protects heart against MI/R injury-induced cardiomyocytes apoptosis by activating lysosomal autophagy.
Title: CREG protects from myocardial ischemia/reperfusion injury by regulating myocardial autophagy and apoptosis.
CREG1 interacts with Sec8 to promote cardiomyogenic differentiation and cell-cell adhesion.
Title: CREG1 Interacts with Sec8 to Promote Cardiomyogenic Differentiation and Cell-Cell Adhesion.
Study demonstrated that haplodeficiency of Creg1 exacerbated high fat diet-induced obesity, insulin resistance and dyslipidemia. In addition, Creg1+/- mice showed increased systemic and adipose tissue inflammation, possibly through activation of the NF-kappaB pathway.
Title: CREG1 heterozygous mice are susceptible to high fat diet-induced obesity and insulin resistance.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA755314 (e-PCR)
- UniSTS:158880

AI844869 (e-PCR)
- UniSTS:165119

Homology

Homologs of the Creg1 gene: The Creg1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, and frog.
Orthologs from Annotation Pipeline: 475 organisms have orthologs with human gene Creg1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables transcription factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lysosomal lumen acidification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lysosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of growth	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein CREG1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.