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ASGR2 asialoglycoprotein receptor 2 [ Homo sapiens (human) ]

Gene ID: 433, updated on 21-Dec-2019

Summary

Official Symbol
ASGR2provided by HGNC
Official Full Name
asialoglycoprotein receptor 2provided by HGNC
Primary source
HGNC:HGNC:743
See related
Ensembl:ENSG00000161944 MIM:108361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HL-2; HBXBP; ASGPR2; ASGP-R2; CLEC4H2
Summary
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Expression
Biased expression in liver (RPKM 120.6) and gall bladder (RPKM 6.7) See more
Orthologs

Genomic context

See ASGR2 in Genome Data Viewer
Location:
17p13.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7101322..7115538, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7004641..7018292, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 member 11 Neighboring gene C-type lectin domain containing 10A Neighboring gene uncharacterized LOC105371512 Neighboring gene ribosomal protein L7a pseudogene 64

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ60040

Gene Ontology Provided by GOA

Function Evidence Code Pubs
asialoglycoprotein receptor activity TAS
Traceable Author Statement
more info
PubMed 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
bone mineralization IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
lipid homeostasis IEA
Inferred from Electronic Annotation
more info
 
protein N-linked glycosylation via asparagine TAS
Traceable Author Statement
more info
 
regulation of protein stability IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum quality control compartment IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
asialoglycoprotein receptor 2
Names
C-type lectin domain family 4 member H2
HBxAg-binding protein
hepatic lectin H2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029064.1 RefSeqGene

    Range
    5001..18490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181.4NP_001172.1  asialoglycoprotein receptor 2 isoform a

    See identical proteins and their annotated locations for NP_001172.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as H2a, differs in the 5' UTR, compared to variant H2'. Variants H2' and 1 encode the same isoform (a).
    Source sequence(s)
    AC120057, BX483468, M11025
    Consensus CDS
    CCDS32544.1
    UniProtKB/Swiss-Prot
    P07307
    Conserved Domains (2) summary
    cd03590
    Location:177302
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:29167
    Lectin_N; Hepatic lectin, N-terminal domain
  2. NM_001201352.1NP_001188281.1  asialoglycoprotein receptor 2 isoform d

    See identical proteins and their annotated locations for NP_001188281.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as H2b, differs in the 5' UTR and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant H2'. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AF529374, BM561839, M11025
    UniProtKB/Swiss-Prot
    P07307
    UniProtKB/TrEMBL
    Q7Z4G9
    Conserved Domains (2) summary
    cd03590
    Location:172297
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:37162
    Lectin_N; Hepatic lectin, N-terminal domain
  3. NM_080912.3NP_550434.1  asialoglycoprotein receptor 2 isoform a

    See identical proteins and their annotated locations for NP_550434.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (H2') represents the longest transcript and encodes the longest isoform (a). Variants H2' and 1 encode the same isoform.
    Source sequence(s)
    AC120057, DC315727, M11025
    Consensus CDS
    CCDS32544.1
    UniProtKB/Swiss-Prot
    P07307
    Related
    ENSP00000347140.5, ENST00000355035.9
    Conserved Domains (2) summary
    cd03590
    Location:177302
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:29167
    Lectin_N; Hepatic lectin, N-terminal domain
  4. NM_080913.3NP_550435.1  asialoglycoprotein receptor 2 isoform b

    See identical proteins and their annotated locations for NP_550435.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as H2c and L-H2, differs in the 5' UTR and uses two alternate splice sites in the 5' coding region, but maintains the reading frame, compared to variant H2'. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    BC017251, BX483468, M11025
    Consensus CDS
    CCDS11088.1
    UniProtKB/Swiss-Prot
    P07307
    Related
    ENSP00000254850.7, ENST00000254850.11
    Conserved Domains (2) summary
    cd03590
    Location:153278
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:18143
    Lectin_N; Hepatic lectin, N-terminal domain
  5. NM_080914.2NP_550436.1  asialoglycoprotein receptor 2 isoform c

    See identical proteins and their annotated locations for NP_550436.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region but maintains the reading frame, compared to variant H2'. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC120057, M11025, U97197, X55284
    Consensus CDS
    CCDS45598.1
    UniProtKB/Swiss-Prot
    P07307
    Related
    ENSP00000405844.2, ENST00000446679.6
    Conserved Domains (2) summary
    cd03590
    Location:158283
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:18148
    Lectin_N; Hepatic lectin, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7101322..7115538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024652.2XP_016880141.1  asialoglycoprotein receptor 2 isoform X7

    UniProtKB/Swiss-Prot
    P07307
    Conserved Domains (2) summary
    cd03590
    Location:177302
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:29167
    Lectin_N; Hepatic lectin, N-terminal domain
  2. XM_017024653.2XP_016880142.1  asialoglycoprotein receptor 2 isoform X7

    UniProtKB/Swiss-Prot
    P07307
    Conserved Domains (2) summary
    cd03590
    Location:177302
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:29167
    Lectin_N; Hepatic lectin, N-terminal domain
  3. XM_011523865.2XP_011522167.1  asialoglycoprotein receptor 2 isoform X2

    See identical proteins and their annotated locations for XP_011522167.1

    Conserved Domains (2) summary
    cd03590
    Location:165290
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:18155
    Lectin_N; Hepatic lectin, N-terminal domain
  4. XM_006721526.2XP_006721589.1  asialoglycoprotein receptor 2 isoform X9

    See identical proteins and their annotated locations for XP_006721589.1

    UniProtKB/Swiss-Prot
    P07307
    Conserved Domains (2) summary
    cd03590
    Location:153278
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:18143
    Lectin_N; Hepatic lectin, N-terminal domain
  5. XM_024450755.1XP_024306523.1  asialoglycoprotein receptor 2 isoform X4

    Conserved Domains (2) summary
    cd03590
    Location:245370
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:110235
    Lectin_N; Hepatic lectin, N-terminal domain
  6. XM_011523862.3XP_011522164.2  asialoglycoprotein receptor 2 isoform X1

  7. XM_005256648.2XP_005256705.1  asialoglycoprotein receptor 2 isoform X9

    See identical proteins and their annotated locations for XP_005256705.1

    UniProtKB/Swiss-Prot
    P07307
    Conserved Domains (2) summary
    cd03590
    Location:153278
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:18143
    Lectin_N; Hepatic lectin, N-terminal domain
  8. XM_011523866.1XP_011522168.1  asialoglycoprotein receptor 2 isoform X2

    See identical proteins and their annotated locations for XP_011522168.1

    Conserved Domains (2) summary
    cd03590
    Location:165290
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:18155
    Lectin_N; Hepatic lectin, N-terminal domain
  9. XM_011523863.3XP_011522165.1  asialoglycoprotein receptor 2 isoform X2

    See identical proteins and their annotated locations for XP_011522165.1

    Conserved Domains (2) summary
    cd03590
    Location:165290
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:18155
    Lectin_N; Hepatic lectin, N-terminal domain
  10. XM_017024651.1XP_016880140.1  asialoglycoprotein receptor 2 isoform X3

    UniProtKB/Swiss-Prot
    P07307
  11. XM_006721524.2XP_006721587.2  asialoglycoprotein receptor 2 isoform X5

    Conserved Domains (2) summary
    cd03590
    Location:114239
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:21104
    Lectin_N; Hepatic lectin, N-terminal domain
  12. XM_011523864.3XP_011522166.1  asialoglycoprotein receptor 2 isoform X6

    See identical proteins and their annotated locations for XP_011522166.1

    Conserved Domains (2) summary
    cd03590
    Location:184309
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:29174
    Lectin_N; Hepatic lectin, N-terminal domain
  13. XM_024450756.1XP_024306524.1  asialoglycoprotein receptor 2 isoform X8

    Conserved Domains (2) summary
    cd03590
    Location:172297
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:37162
    Lectin_N; Hepatic lectin, N-terminal domain
  14. XM_024450757.1XP_024306525.1  asialoglycoprotein receptor 2 isoform X5

    Conserved Domains (2) summary
    cd03590
    Location:114239
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:21104
    Lectin_N; Hepatic lectin, N-terminal domain
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