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Otulin OTU deubiquitinase with linear linkage specificity [ Mus musculus (house mouse) ]

Gene ID: 432940, updated on 8-Feb-2024

Summary

Official Symbol
Otulinprovided by MGI
Official Full Name
OTU deubiquitinase with linear linkage specificityprovided by MGI
Primary source
MGI:MGI:3577015
See related
Ensembl:ENSMUSG00000046034 AllianceGenome:MGI:3577015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
m3Sapc; Fam105b; m7-1Sapc
Summary
Enables thiol-dependent deubiquitinase. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; protein linear deubiquitination; and regulation of signal transduction. Located in cytoplasm. Part of LUBAC complex. Is expressed in several structures, including branchial arch; cardiovascular system; genitourinary system; gut; and hemolymphoid system. Human ortholog(s) of this gene implicated in otulipenia. Orthologous to human OTULIN (OTU deubiquitinase with linear linkage specificity). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 20.9), ovary adult (RPKM 16.5) and 28 other tissues See more
Orthologs
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Genomic context

See Otulin in Genome Data Viewer
Location:
15 B1; 15 10.31 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (27606005..27630793, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (27597055..27630977, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene progressive ankylosis Neighboring gene predicted gene, 29901 Neighboring gene STARR-seq mESC enhancer starr_38227 Neighboring gene microRNA 7117 Neighboring gene STARR-positive B cell enhancer mm9_chr15:27526573-27526874 Neighboring gene STARR-positive B cell enhancer mm9_chr15:27560352-27560653 Neighboring gene predicted gene, 46506 Neighboring gene OTU deubiquitinase with linear linkage specificity like Neighboring gene STARR-seq mESC enhancer starr_38229

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein linear deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein linear deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein linear deubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of LUBAC complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin thioesterase otulin
Names
OTU domain-containing deubiquitinase with linear linkage specificity
deubiquitinating enzyme otulin
family with sequence similarity 105, member B
gumby
protein FAM105B
ubiquitin thioesterase Gumby
NP_001013814.2
NP_001402972.1
NP_001402974.1
NP_001402975.1
NP_001402976.1
NP_001402977.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013792.3NP_001013814.2  ubiquitin thioesterase otulin isoform 1

    See identical proteins and their annotated locations for NP_001013814.2

    Status: VALIDATED

    Source sequence(s)
    AC158955
    Consensus CDS
    CCDS49586.1
    UniProtKB/Swiss-Prot
    Q3UCV8, Q3UY59, Q5M8N1, Q8R027
    Related
    ENSMUSP00000057893.8, ENSMUST00000059662.8
    Conserved Domains (1) summary
    pfam16218
    Location:81344
    Peptidase_C101; Peptidase family C101
  2. NM_001416043.1NP_001402972.1  ubiquitin thioesterase otulin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158955
  3. NM_001416045.1NP_001402974.1  ubiquitin thioesterase otulin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158955
  4. NM_001416046.1NP_001402975.1  ubiquitin thioesterase otulin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158955
  5. NM_001416047.1NP_001402976.1  ubiquitin thioesterase otulin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158955
  6. NM_001416048.1NP_001402977.1  ubiquitin thioesterase otulin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158955

RNA

  1. NR_183245.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158955

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    27606005..27630793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)