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Zfp708 zinc finger protein 708 [ Mus musculus (house mouse) ]

Gene ID: 432769, updated on 27-Nov-2024

Summary

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Official Symbol
Zfp708provided by MGI
Official Full Name
zinc finger protein 708provided by MGI
Primary source
MGI:MGI:3040674
See related
Ensembl:ENSMUSG00000058883 AllianceGenome:MGI:3040674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rslcan11
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF28 (zinc finger protein 28); ZNF429 (zinc finger protein 429); and ZNF611 (zinc finger protein 611). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 2.3), CNS E14 (RPKM 2.1) and 22 other tissues See more
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Genomic context

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See Zfp708 in Genome Data Viewer
Location:
13 B3; 13 34.54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67217462..67246040, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67069398..67097976, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene phosphatidylserine synthase 1 Neighboring gene RIKEN cDNA 4933433G19 gene Neighboring gene STARR-seq mESC enhancer starr_34892 Neighboring gene zinc finger protein 712 Neighboring gene STARR-positive B cell enhancer ABC_E3085 Neighboring gene STARR-positive B cell enhancer ABC_E9879 Neighboring gene uncharacterized LOC118568057 Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1465 Neighboring gene regulator of sex-limitation candidate 18 Neighboring gene zinc finger protein 759 Neighboring gene STARR-seq mESC enhancer starr_34894 Neighboring gene STARR-positive B cell enhancer ABC_E2411 Neighboring gene regulator of sex limited protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons. Seah MKY, et al. Development, 2019 Jul 10. PMID 30846446, Free PMC Article
  2. Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2. Krebs CJ, et al. Genomics, 2005 Jun. PMID 15885501
  3. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs CJ, et al. Genes Dev, 2003 Nov 1. PMID 14563677, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZFP708 recruits the repressive TRIM28 complex to RMER19B retrotransposons to evoke regional heterochromatin formation.
    Title: The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC102251

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 708
Names
regulator of sex-limitation candidate 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012325.2 → NP_001012325.2  zinc finger protein 708 isoform a

    See identical proteins and their annotated locations for NP_001012325.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC089368, CF174027
    UniProtKB/TrEMBL
    F8VPP0
    Related
    ENSMUSP00000105365.4, ENSMUST00000109743.5
    Conserved Domains (5) summary
    smart00349
    Location:17 → 77
    KRAB; krueppel associated box
    COG5048
    Location:119 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:17 → 56
    KRAB; KRAB box
    pfam13465
    Location:303 → 328
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001012448.2 → NP_001012450.2  zinc finger protein 708 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    BB612019, BC089368
    Consensus CDS
    CCDS49298.1
    UniProtKB/TrEMBL
    F2Z422
    Related
    ENSMUSP00000105364.4, ENSMUST00000109742.11
    Conserved Domains (5) summary
    smart00349
    Location:5 → 65
    KRAB; krueppel associated box
    COG5048
    Location:107 → 528
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:279 → 299
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5 → 44
    KRAB; KRAB box
    pfam13465
    Location:291 → 316
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001012449.2 → NP_001012451.2  zinc finger protein 708 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform c).
    Source sequence(s)
    BC089368, CF174027
    Conserved Domains (5) summary
    smart00349
    Location:17 → 62
    KRAB; krueppel associated box
    COG5048
    Location:87 → 508
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:17 → 56
    KRAB; KRAB box
    pfam13465
    Location:271 → 296
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001292066.1 → NP_001278995.1  zinc finger protein 708 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK132353, BC089368
    Consensus CDS
    CCDS79206.1
    UniProtKB/TrEMBL
    A0A087WPV0
    Related
    ENSMUSP00000139928.2, ENSMUST00000190566.3
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:74 → 495
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:246 → 266
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:258 → 283
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    67217462..67246040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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