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MMP17 matrix metallopeptidase 17 [ Homo sapiens (human) ]

Gene ID: 4326, updated on 5-Dec-2018

Summary

Official Symbol
MMP17provided by HGNC
Official Full Name
matrix metallopeptidase 17provided by HGNC
Primary source
HGNC:HGNC:7163
See related
Ensembl:ENSG00000198598 MIM:602285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MMP-17; MT4MMP; MTMMP4; MT4-MMP
Summary
This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016]
Expression
Broad expression in brain (RPKM 3.8), skin (RPKM 1.6) and 16 other tissues See more
Orthologs

Genomic context

See MMP17 in Genome Data Viewer
Location:
12q24.33
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (131828393..131851771)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (132312941..132336316)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370088 Neighboring gene RNA, U6 small nuclear 1017, pseudogene Neighboring gene unc-51 like autophagy activating kinase 1 Neighboring gene uncharacterized LOC107984455

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
NHGRI GWA Catalog

Pathways from BioSystems

  • Activation of Matrix Metalloproteinases, organism-specific biosystem (from REACTOME)
    Activation of Matrix Metalloproteinases, organism-specific biosystemThe matrix metalloproteinases (MMPs), previously known as matrixins, are classically known to be involved in the turnover of extracellular matrix (ECM) components. However, recent high throughput pro...
  • Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
    Degradation of the extracellular matrix, organism-specific biosystemMatrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Matrix Metalloproteinases, organism-specific biosystem (from WikiPathways)
    Matrix Metalloproteinases, organism-specific biosystemMatrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme activator activity TAS
Traceable Author Statement
more info
PubMed 
metalloaminopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
drinking behavior IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kidney development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
matrix metalloproteinase-17
Names
MT-MMP 4
matrix metallopeptidase 17 (membrane-inserted)
matrix metalloproteinase 17 (membrane-inserted)
membrane-type matrix metalloproteinase 4
membrane-type-4 matrix metalloproteinase
NP_057239.4
XP_011536657.1
XP_011536658.1
XP_011536659.1
XP_016874796.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016155.7NP_057239.4  matrix metalloproteinase-17 preproprotein

    See identical proteins and their annotated locations for NP_057239.4

    Status: REVIEWED

    Source sequence(s)
    AC131009
    Consensus CDS
    CCDS31927.1
    UniProtKB/Swiss-Prot
    Q9ULZ9
    Related
    ENSP00000353767.1, ENST00000360564.5
    Conserved Domains (4) summary
    cd00094
    Location:329523
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:132295
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:132295
    Peptidase_M10; Matrixin
    pfam01471
    Location:47105
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    131828393..131851771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019307.1XP_016874796.1  matrix metalloproteinase-17 isoform X2

  2. XM_011538357.2XP_011536659.1  matrix metalloproteinase-17 isoform X1

    See identical proteins and their annotated locations for XP_011536659.1

    UniProtKB/Swiss-Prot
    Q9ULZ9
    Related
    ENSP00000441106.1, ENST00000535291.5
    Conserved Domains (4) summary
    cd00094
    Location:245439
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:48211
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:48211
    Peptidase_M10; Matrixin
    pfam01471
    Location:121
    PG_binding_1; Putative peptidoglycan binding domain
  3. XM_011538355.3XP_011536657.1  matrix metalloproteinase-17 isoform X1

    See identical proteins and their annotated locations for XP_011536657.1

    UniProtKB/Swiss-Prot
    Q9ULZ9
    Conserved Domains (4) summary
    cd00094
    Location:245439
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:48211
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:48211
    Peptidase_M10; Matrixin
    pfam01471
    Location:121
    PG_binding_1; Putative peptidoglycan binding domain
  4. XM_011538356.3XP_011536658.1  matrix metalloproteinase-17 isoform X1

    See identical proteins and their annotated locations for XP_011536658.1

    UniProtKB/Swiss-Prot
    Q9ULZ9
    Conserved Domains (4) summary
    cd00094
    Location:245439
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:48211
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:48211
    Peptidase_M10; Matrixin
    pfam01471
    Location:121
    PG_binding_1; Putative peptidoglycan binding domain

RNA

  1. XR_944550.2 RNA Sequence

  2. XR_001748705.1 RNA Sequence

  3. XR_944552.2 RNA Sequence

  4. XR_944551.2 RNA Sequence

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