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Adcy1 adenylate cyclase 1 [ Mus musculus (house mouse) ]

Gene ID: 432530, updated on 27-Nov-2024

Summary

Official Symbol
Adcy1provided by MGI
Official Full Name
adenylate cyclase 1provided by MGI
Primary source
MGI:MGI:99677
See related
Ensembl:ENSMUSG00000020431 AllianceGenome:MGI:99677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AC1; brl; I-AC; D11Bwg1392e
Summary
Enables adenylate cyclase activity. Involved in several processes, including modulation of chemical synaptic transmission; neuroinflammatory response; and positive regulation of CREB transcription factor activity. Acts upstream of or within axonogenesis and long-term memory. Located in cytoplasm and postsynaptic density. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 44. Orthologous to human ADCY1 (adenylate cyclase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 78.9), cortex adult (RPKM 50.8) and 4 other tissues See more
Orthologs
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Genomic context

See Adcy1 in Genome Data Viewer
Location:
11 A1; 11 4.72 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (7013433..7128506)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (7063433..7178506)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57582 Neighboring gene STARR-seq mESC enhancer starr_28478 Neighboring gene STARR-seq mESC enhancer starr_28479 Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28481 Neighboring gene STARR-seq mESC enhancer starr_28484 Neighboring gene coiled coil domain 201 Neighboring gene insulin-like growth factor binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4070

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenylate cyclase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
enables calcium- and calmodulin-responsive adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium- and calmodulin-responsive adenylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cAMP biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to forskolin ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within long-term memory IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuroinflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of CREB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adenylate cyclase type 1
Names
ATP pyrophosphate-lyase 1
Ca(2+)/calmodulin-activated adenylyl cyclase
adenylate cyclase type I
adenylyl cyclase 1
barrelless
NP_033752.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009622.2NP_033752.1  adenylate cyclase type 1

    See identical proteins and their annotated locations for NP_033752.1

    Status: VALIDATED

    Source sequence(s)
    AL669838
    Consensus CDS
    CCDS24426.1
    UniProtKB/Swiss-Prot
    O88444, Q5SS89
    Related
    ENSMUSP00000020706.5, ENSMUST00000020706.5
    Conserved Domains (3) summary
    smart00044
    Location:257452
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:8581055
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:158291
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    7013433..7128506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)