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Akap7 A kinase anchor protein 7 [ Mus musculus (house mouse) ]

Gene ID: 432442, updated on 8-Feb-2024

Summary

Official Symbol
Akap7provided by MGI
Official Full Name
A kinase anchor protein 7provided by MGI
Primary source
MGI:MGI:1859150
See related
Ensembl:ENSMUSG00000039166 AllianceGenome:MGI:1859150
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AKAP15; Akap18; 6430401D08
Summary
Enables protein kinase A regulatory subunit binding activity and protein kinase binding activity. Involved in modulation of chemical synaptic transmission. Located in cytoplasm; hippocampal mossy fiber to CA3 synapse; and nucleus. Is expressed in several structures, including cartilage; endocrine gland; genitourinary system; telencephalon; and trachea. Orthologous to human AKAP7 (A-kinase anchoring protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 6.0), CNS E18 (RPKM 4.9) and 24 other tissues See more
Orthologs
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Genomic context

See Akap7 in Genome Data Viewer
Location:
10 A4; 10 12.26 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (25044988..25175115, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (25169090..25299217, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene actin, gamma, cytoplasmic 1 pseudogene Neighboring gene predicted gene, 36313 Neighboring gene STARR-seq mESC enhancer starr_26094 Neighboring gene STARR-seq mESC enhancer starr_26095 Neighboring gene STARR-seq mESC enhancer starr_26096 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene predicted gene, 25016 Neighboring gene STARR-seq mESC enhancer starr_26098 Neighboring gene predicted gene, 40617 Neighboring gene STARR-seq mESC enhancer starr_26101 Neighboring gene erythrocyte membrane protein band 4.1 like 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:25123932-25124041 Neighboring gene small leucine-rich protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AMP binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase A regulatory subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in exocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
A-kinase anchor protein 7
Names
A kinase (PRKA) anchor protein 7
A-kinase anchor protein 18
A-kinase anchor protein 9 kDa
AKAP 9
AKAP-18
protein kinase A anchoring protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347460.2NP_001334389.1  A-kinase anchor protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153549
    Consensus CDS
    CCDS83688.1
    UniProtKB/Swiss-Prot
    G3X9Q5, O55074
    Related
    ENSMUSP00000097590.3, ENSMUST00000100012.3
    Conserved Domains (1) summary
    pfam10470
    Location:2379
    AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
  2. NM_001379238.1NP_001366167.1  A-kinase anchor protein 7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC153549, AC153550
    UniProtKB/Swiss-Prot
    F8VQ58, Q7TN79
    Conserved Domains (2) summary
    pfam10470
    Location:256311
    AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
    pfam10469
    Location:51249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  3. NM_001379239.1NP_001366168.1  A-kinase anchor protein 7 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (3).
    Source sequence(s)
    AC153549, AC153550
    Conserved Domains (1) summary
    pfam10469
    Location:51249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  4. NM_001379240.1NP_001366169.1  A-kinase anchor protein 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153550
    UniProtKB/TrEMBL
    Q4KL21
    Related
    ENSMUSP00000093455.5, ENSMUST00000095779.11
  5. NM_018747.5NP_061217.3  A-kinase anchor protein 7 isoform 1

    See identical proteins and their annotated locations for NP_061217.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variant 3, encodes isoform 1.
    Source sequence(s)
    AC153549, AC153550
    Consensus CDS
    CCDS23753.1
    UniProtKB/Swiss-Prot
    F8VQ58, Q7TN79
    Related
    ENSMUSP00000043624.8, ENSMUST00000041984.14
    Conserved Domains (2) summary
    pfam10470
    Location:256311
    AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
    pfam10469
    Location:51249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

RNA

  1. NR_166567.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153549, AC153550
  2. NR_166568.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153549, AC153550
  3. NR_166569.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153549

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    25044988..25175115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512788.4XP_006512851.1  A-kinase anchor protein 7 isoform X2

    See identical proteins and their annotated locations for XP_006512851.1

    Conserved Domains (1) summary
    pfam10469
    Location:51249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  2. XM_030245157.2XP_030101017.1  A-kinase anchor protein 7 isoform X3

    UniProtKB/Swiss-Prot
    F8VQ58, Q7TN79
    Conserved Domains (2) summary
    pfam10470
    Location:256311
    AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
    pfam10469
    Location:51249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  3. XM_030245156.1XP_030101016.1  A-kinase anchor protein 7 isoform X2

    Conserved Domains (1) summary
    pfam10469
    Location:51249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  4. XM_006512790.3XP_006512853.1  A-kinase anchor protein 7 isoform X2

    See identical proteins and their annotated locations for XP_006512853.1

    Conserved Domains (1) summary
    pfam10469
    Location:51249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  5. XM_036155887.1XP_036011780.1  A-kinase anchor protein 7 isoform X2

    Conserved Domains (1) summary
    pfam10469
    Location:51249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  6. XM_006512789.2XP_006512852.1  A-kinase anchor protein 7 isoform X2

    See identical proteins and their annotated locations for XP_006512852.1

    Conserved Domains (1) summary
    pfam10469
    Location:51249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  7. XM_006512791.5XP_006512854.1  A-kinase anchor protein 7 isoform X2

    See identical proteins and their annotated locations for XP_006512854.1

    Conserved Domains (1) summary
    pfam10469
    Location:51249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  8. XM_006512793.5XP_006512856.1  A-kinase anchor protein 7 isoform X4

    See identical proteins and their annotated locations for XP_006512856.1

    Conserved Domains (1) summary
    pfam10469
    Location:6164
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  9. XM_006512794.5XP_006512857.1  A-kinase anchor protein 7 isoform X4

    See identical proteins and their annotated locations for XP_006512857.1

    Conserved Domains (1) summary
    pfam10469
    Location:6164
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  10. XM_017314023.3XP_017169512.1  A-kinase anchor protein 7 isoform X5

    Conserved Domains (1) summary
    pfam10470
    Location:46102
    AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
  11. XM_036155886.1XP_036011779.1  A-kinase anchor protein 7 isoform X1

    Conserved Domains (1) summary
    pfam10469
    Location:187385
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

RNA

  1. XR_001779549.3 RNA Sequence

  2. XR_003948725.2 RNA Sequence

  3. XR_001779547.3 RNA Sequence

  4. XR_001779546.3 RNA Sequence

  5. XR_380068.5 RNA Sequence

  6. XR_380067.3 RNA Sequence