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CSNK2A1 casein kinase 2 alpha 1 [ Gallus gallus (chicken) ]

Gene ID: 432370, updated on 10-Oct-2019

Summary

Symbol
CSNK2A1provided by CGNC
Full Name
casein kinase 2 alpha 1provided by CGNC
Primary source
CGNC:54315
See related
Ensembl:ENSGALG00000006197
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Summary
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]
Orthologs

Genomic context

See CSNK2A1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
17
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) 20 NC_006107.5 (9935278..9957819)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 20 NC_006107.4 (10136327..10158922)
102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 20 NC_006107.3 (10279230..10300794)

Chromosome 20 - NC_006107.5Genomic Context describing neighboring genes Neighboring gene sulfiredoxin 1 Neighboring gene transcription factor 15 (basic helix-loop-helix) Neighboring gene TBC1 domain family member 20 Neighboring gene neurensin 2

Genomic regions, transcripts, and products

Pathways from BioSystems

  • Adherens junction, organism-specific biosystem (from KEGG)
    Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Adherens junction, conserved biosystem (from KEGG)
    Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Mitophagy - animal, organism-specific biosystem (from KEGG)
    Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Mitophagy - animal, conserved biosystem (from KEGG)
    Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with PcG protein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
casein kinase II subunit alpha
Names
CK II
casein kinase 2, alpha 1 polypeptide
casein kinase II alpha subunit
NP_001002242.1
XP_015151905.1
XP_024998034.1
XP_024998035.1
XP_024998036.1
XP_024998037.1
XP_024998038.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002242.1NP_001002242.1  casein kinase II subunit alpha

    See identical proteins and their annotated locations for NP_001002242.1

    Status: PROVISIONAL

    Source sequence(s)
    M59456
    UniProtKB/Swiss-Prot
    P21868
    Related
    ENSGALP00000009985.3, ENSGALT00000009999.6
    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_006107.5 Reference GRCg6a Primary Assembly

    Range
    9935278..9957819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015296419.2XP_015151905.1  casein kinase II subunit alpha isoform X1

    UniProtKB/Swiss-Prot
    P21868
    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  2. XM_025142266.1XP_024998034.1  casein kinase II subunit alpha isoform X1

    Related
    ENSGALP00000042162.1, ENSGALT00000043417.4
    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  3. XM_025142268.1XP_024998036.1  casein kinase II subunit alpha isoform X1

    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  4. XM_025142267.1XP_024998035.1  casein kinase II subunit alpha isoform X1

    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  5. XM_025142270.1XP_024998038.1  casein kinase II subunit alpha isoform X1

    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  6. XM_025142269.1XP_024998037.1  casein kinase II subunit alpha isoform X1

    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
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