Tl Toll [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tlprovided by FlyBase
Official Full Name: Tollprovided by FlyBase
Primary source: FLYBASE:FBgn0262473
Locus tag: Dmel_CG5490
See related: AllianceGenome:FB:FBgn0262473
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5490; CT17414; Dmel\CG5490; dToll; dToll1; EP(3)1051; EP1051; Fs(1)Tl; Fs(3)Tl; mat(3)9; mel(3)10; mel(3)9; T1; tl; TL; TOL; toll; TOLL; toll-1; Toll-1; Toll1; Toll10B
Summary: Enables several functions, including TIR domain binding activity; cytokine receptor activity; and virion binding activity. Involved in several processes, including defense response to other organism; nervous system development; and positive regulation of macromolecule biosynthetic process. Located in cleavage furrow; early endosome; and external side of plasma membrane. Is expressed in several structures, including ISN innervated muscle cell of A1-7; adult head; embryonic dorsal vessel; embryonic/larval aorta; and embryonic/larval heart. Used to study collagen disease; glucose metabolism disease; and primary immunodeficiency disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); dermatitis (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including TLR1 (toll like receptor 1); TLR10 (toll like receptor 10); and TLR2 (toll like receptor 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Genomic context

Location:: 97D2-97D2; 3-92 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (26799041..26842403)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (22624763..22668125)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An unusual Toll/MyD88-mediated Drosophila host defence against Talaromyces marneffei.
Title: An unusual Toll/MyD88-mediated Drosophila host defence against Talaromyces marneffei.
An evolutionarily conserved serine protease network mediates melanization and Toll activation in Drosophila.
Title: An evolutionarily conserved serine protease network mediates melanization and Toll activation in Drosophila.
The identification of regulatory ceRNA network involved in Drosophila Toll immune responses.
Title: The identification of regulatory ceRNA network involved in Drosophila Toll immune responses.
The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins.
Title: The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins.
Bacterial recognition by PGRP-SA and downstream signalling by Toll/DIF sustain commensal gut bacteria in Drosophila.
Title: Bacterial recognition by PGRP-SA and downstream signalling by Toll/DIF sustain commensal gut bacteria in Drosophila.
Differential cell adhesion implemented by Drosophila Toll corrects local distortions of the anterior-posterior compartment boundary.
Title: Differential cell adhesion implemented by Drosophila Toll corrects local distortions of the anterior-posterior compartment boundary.
Invertebrate Iridescent Virus-6 is capable of inhibiting the two Drosophila NF-kappaB signaling pathways, Imd and Toll.
Title: IIV-6 Inhibits NF-κB Responses in Drosophila.
Spz5, a member of the Spz family of proteins, functions as a ligand for the Toll-1 receptor.
Title: Characterization of Spz5 as a novel ligand for Drosophila Toll-1 receptor.
The Toll pathway is dimorphic in genome-wide constitutive gene expression and in induced response to infection
Title: The Toll pathway underlies host sexual dimorphism in resistance to both Gram-negative and Gram-positive bacteria in mated Drosophila.
Cic regulated spatially restricted expression of Toll/IL-1 signaling targets in Drosophila embryogenesis.
Title: Capicua controls Toll/IL-1 signaling targets independently of RTK regulation.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables TIR domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables virion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Toll signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Toll signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antifungal innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in antifungal innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell competition in a multicellular organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to oomycetes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of virus	IDA Inferred from Direct Assay more info	PubMed
involved_in dorsal/ventral axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antifungal peptide production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of antifungal peptide production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of antimicrobial peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to tumor cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic target inhibition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	EXP Inferred from Experiment more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	EXP Inferred from Experiment more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: toll

Names: CG5490-PB; CG5490-PC; CG5490-PD; EP1051; TOLL; Tl-PB; Tl-PC; Tl-PD; Toll-1; protein toll precursor; toll receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

26799041..26842403

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079794.3 → NP_524518.1 toll, isoform B

See identical proteins and their annotated locations for NP_524518.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3G7, A8WHK7, P08953, Q8MRF3, Q9VBB8

UniProtKB/TrEMBL

T2GGK5

Related

FBpp0084431

Conserved Domains (6) summary

smart00013
Location:631 → 667

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:561 → 619

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:858 → 996

TIR; Toll - interleukin 1 - resistance

cd00116
Location:216 → 542

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:271 → 294

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:390 → 450

LRR_8; Leucine rich repeat
NM_001276066.2 → NP_001262995.1 toll, isoform C

See identical proteins and their annotated locations for NP_001262995.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHY4

Conserved Domains (6) summary

smart00013
Location:631 → 667

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:561 → 619

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:858 → 996

TIR; Toll - interleukin 1 - resistance

cd00116
Location:216 → 542

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:271 → 294

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:390 → 450

LRR_8; Leucine rich repeat
NM_170287.3 → NP_733166.1 toll, isoform D

See identical proteins and their annotated locations for NP_733166.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3G7, A8WHK7, P08953, Q8MRF3, Q9VBB8

UniProtKB/TrEMBL

T2GGK5

Related

FBpp0303188

Conserved Domains (6) summary

smart00013
Location:631 → 667

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:561 → 619

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:858 → 996

TIR; Toll - interleukin 1 - resistance

cd00116
Location:216 → 542

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:271 → 294

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:390 → 450

LRR_8; Leucine rich repeat