igf2.L insulin like growth factor 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: igf2.L
Official Full Name: insulin like growth factor 2 L homeolog
Primary source: Xenbase:XB-GENE-864886
Locus tag: XELAEV_18022013mg
See related: EnsemblRapid:ENSXLAG00005020607 AllianceGenome:Xenbase:XB-GENE-864886
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: igf2; igf-2; IGF-II; igf2-a; igf2-b; insigf; pp9974
Summary: Predicted to enable growth factor activity and integrin binding activity. Predicted to act upstream of or within head morphogenesis; nervous system development; and positive regulation of cell population proliferation. Predicted to be located in extracellular space. Is expressed in urinary system. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 4L

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (16480155..16518326, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (15965120..16002160, complement)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within head morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like growth factor 2.L; insulin-like growth factor II-B

Names: IGF-II-B; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor 2-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091660.1 → NP_001085129.2 insulin-like growth factor 2.L precursor

See identical proteins and their annotated locations for NP_001085129.2

Status: PROVISIONAL

Source sequence(s)

BC072153

UniProtKB/Swiss-Prot

Q6INW9

UniProtKB/TrEMBL

A0A974D1J3

Related

ENSXLAP00005060403.1, ENSXLAT00005061852.1

Conserved Domains (2) summary

cd04368
Location:59 → 123

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

pfam08365
Location:150 → 205

IGF2_C; Insulin-like growth factor II E-peptide

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

16480155..16518326 complement

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GenBank, FASTA, Sequence Viewer (Graphics)