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smad2.S SMAD family member 2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 432023, updated on 5-Sep-2025
Official Symbol
smad2.S
Official Full Name
SMAD family member 2 S homeolog
Primary source
Xenbase:XB-GENE-864923
Locus tag
XELAEV_18011112mg
See related
EnsemblRapid:ENSXLAG00005002500 AllianceGenome:Xenbase:XB-GENE-864923
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
smad2; XSmad2; smad-2
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within axis elongation. Predicted to be located in cytosol. Predicted to be part of transcription regulator complex. Is expressed in musculoskeletal system; nervous system; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 6; Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2). [provided by Alliance of Genome Resources, Jul 2025]
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See smad2.S in Genome Data Viewer
Location:
chromosome: 1S
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (194039786..194078970)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (174261503..174286770)

Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD58 Neighboring gene ribosomal protein L17 S homeolog Neighboring gene zinc finger and BTB domain containing 7C S homeolog Neighboring gene SKI family transcriptional corepressor 2 S homeolog Neighboring gene immediate early response 3 interacting protein 1 S homeolog

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo. Ho DM, et al. Mech Dev, 2010 Sep-Dec. PMID 20807570, Free PMC Article
  2. E2a is necessary for Smad2/3-dependent transcription and the direct repression of lefty during gastrulation. Wills AE, et al. Dev Cell, 2015 Feb 9. PMID 25669884, Free PMC Article
  3. Negative regulation of Smad2 by PIASy is required for proper Xenopus mesoderm formation. Daniels M, et al. Development, 2004 Nov. PMID 15496439
  4. Smad2 and Smad3 differentially modulate chordin transcription via direct binding on the distal elements in gastrula Xenopus embryos. Kumar V, et al. Biochem Biophys Res Commun, 2021 Jun 25. PMID 33945994
  5. FoxH1 mediates a Grg4 and Smad2 dependent transcriptional switch in Nodal signaling during Xenopus mesoderm development. Reid CD, et al. Dev Biol, 2016 Jun 1. PMID 27085753, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Smad2 and Smad3 differentially modulate chordin transcription via direct binding on the distal elements in gastrula Xenopus embryos.
    Title: Smad2 and Smad3 differentially modulate chordin transcription via direct binding on the distal elements in gastrula Xenopus embryos.
  2. Grg4 occupancy at the Xnr1 enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 from FoxH1 at the Xnr1 enhancer, an essential feature of the transcriptional switch mechanism.
    Title: FoxH1 mediates a Grg4 and Smad2 dependent transcriptional switch in Nodal signaling during Xenopus mesoderm development.
  3. E2a is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis
    Title: E2a is necessary for Smad2/3-dependent transcription and the direct repression of lefty during gastrulation.
  4. GDF11 has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.
    Title: The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo.
  5. XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.
    Title: Negative regulation of Smad2 by PIASy is required for proper Xenopus mesoderm formation.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC81131

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axis elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
SMAD family member 2 S homeolog

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091495.1 → NP_001084964.1  SMAD family member 2 S homeolog

    See identical proteins and their annotated locations for NP_001084964.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070584
    UniProtKB/TrEMBL
    A0A974E2N8, Q6IRR4, Q91912
    Related
    ENSXLAP00005007494.1, ENSXLAT00005007603.1
    Conserved Domains (2) summary
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:8 → 172
    MH1; N-terminal Mad Homology 1 (MH1) domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    194039786..194078970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041574890.1 → XP_041430824.1  SMAD family member 2 S homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J1LNQ3, A0A974E2N8, Q91912
    Conserved Domains (2) summary
    cl00055
    Location:8 → 172
    MH1; N-terminal Mad Homology 1 (MH1) domain
    cl00056
    Location:254 → 385
    MH2; C-terminal Mad Homology 2 (MH2) domain

  2. XM_041574880.1 → XP_041430814.1  SMAD family member 2 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A974E2N8, Q6IRR4, Q91912
    Conserved Domains (2) summary
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:8 → 172
    MH1; N-terminal Mad Homology 1 (MH1) domain

  3. XM_041574886.1 → XP_041430820.1  SMAD family member 2 S homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1LQ33, A0A974E2N8, Q91912
    Related
    ENSXLAP00005007502.1, ENSXLAT00005007611.1
    Conserved Domains (2) summary
    cd10491
    Location:8 → 142
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:236 → 426
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
Nucleotide Protein Strain
Heading Accession and Version

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