rcor2.L REST corepressor 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: rcor2.L
Official Full Name: REST corepressor 2 L homeolog
Primary source: Xenbase:XB-GENE-6251773
Locus tag: XELAEV_18022228mg
See related: EnsemblRapid:ENSXLAG00005020080
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: rcor2; XCoREST
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Genomic context

Location:: chromosome: 4L

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (27229605..27246146)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (25706082..25722632)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data reveal a RCOR2/ZMYND8 complex which might be involved in the regulation of neural differentiation.
Title: Xenopus RCOR2 (REST corepressor 2) interacts with ZMYND8, which is involved in neural differentiation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of histone deacetylase complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: REST corepressor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091315.1 → NP_001084784.1 REST corepressor 2

See identical proteins and their annotated locations for NP_001084784.1

Status: PROVISIONAL

Source sequence(s)

BC070565

UniProtKB/Swiss-Prot

Q6NRZ0

UniProtKB/TrEMBL

A0A974D1Z5

Conserved Domains (3) summary

pfam00249
Location:331 → 374

Myb_DNA-binding; Myb-like DNA-binding domain

pfam01448
Location:43 → 95

ELM2; ELM2 domain

cl21498
Location:131 → 175

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

27229605..27246146

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041589230.1 → XP_041445164.1 REST corepressor 2 isoform X2

UniProtKB/TrEMBL

A0A8J1MTK4

Conserved Domains (1) summary

cl21498
Location:131 → 175

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_018256617.2 → XP_018112106.1 REST corepressor 2 isoform X1

UniProtKB/TrEMBL

A0A8J0V2V5

Related

ENSXLAP00005058789.1, ENSXLAT00005060228.1