acaa1 acetyl-CoA acyltransferase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: acaa1provided by ZNC
Official Full Name: acetyl-CoA acyltransferase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040704-48
See related: Ensembl:ENSDARG00000004687 AllianceGenome:ZFIN:ZDB-GENE-040704-48
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92385
Summary: Predicted to enable acetyl-CoA C-acyltransferase activity. Predicted to be involved in fatty acid beta-oxidation and phenylacetate catabolic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be active in peroxisome. Is expressed in gut; liver; subcutaneous fat; and visceral fat. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	24	NC_133199.1 (24197227..24204240)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (20325447..20332460)

Chromosome 24 - NC_133199.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acetyl-CoA C-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA C-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phenylacetate catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 3-ketoacyl-CoA thiolase, peroxisomal

Names: acetyl-Coenzyme A acyltransferase 1

NP_001002207.1

EC 2.3.1.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002207.1 → NP_001002207.1 3-ketoacyl-CoA thiolase, peroxisomal

See identical proteins and their annotated locations for NP_001002207.1

Status: PROVISIONAL

Source sequence(s)

BC072706

UniProtKB/TrEMBL

B2GTG6, F6P9B2, Q6GQN6

Related

ENSDARP00000017622.6, ENSDART00000007997.8

Conserved Domains (2) summary

PLN02287
Location:1 → 414

PLN02287; 3-ketoacyl-CoA thiolase

cd00751
Location:33 → 415

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...