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mgat4b alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B [ Danio rerio (zebrafish) ]

Gene ID: 431727, updated on 9-Sep-2025
Official Symbol
mgat4bprovided by ZNC
Official Full Name
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040704-19
See related
Ensembl:ENSDARG00000004115 AllianceGenome:ZFIN:ZDB-GENE-040704-19
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92425; wu:fc25g12; mgat4bQ9UQ53
Summary
Predicted to enable alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human MGAT4B (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See mgat4b in Genome Data Viewer
Location:
chromosome: 14
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 14 NC_133189.1 (18858464..19129823, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 14 NC_007125.7 (16483926..16754249, complement)

Chromosome 14 - NC_133189.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141377494 Neighboring gene calnexin Neighboring gene sequestosome 1 Neighboring gene MRN complex interacting protein Neighboring gene T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Mgat4b-mediated selective N-glycosylation regulates melanocyte development and melanoma progression. Sharma B, et al. Proc Natl Acad Sci U S A, 2025 Jun 3. PMID 40424122, Free PMC Article
  2. Profiling DNA methylation patterns of zebrafish liver associated with parental high dietary arachidonic acid. Adam AC, et al. PLoS One, 2019. PMID 31398226, Free PMC Article
  3. Calnexin is required for zebrafish posterior lateral line development. Hung IC, et al. Int J Dev Biol, 2013. PMID 23873374
  4. O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder. Matheny-Rabun C, et al. Cell Rep, 2024 Nov 26. PMID 39561044, Free PMC Article
  5. Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. Zheng W, et al. PLoS One, 2014. PMID 24633177, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
Names
N-acetylglucosaminyltransferase IVb
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb
UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb
glcNAc-T IVb
gnT-IVb
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
NP_001002180.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002180.1 → NP_001002180.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

    See identical proteins and their annotated locations for NP_001002180.1

    Status: PROVISIONAL

    Source sequence(s)
    BC074045
    UniProtKB/Swiss-Prot
    Q6GMK0
    Related
    ENSDARP00000000748.9, ENSDART00000001159.11
    Conserved Domains (1) summary
    pfam04666
    Location:109 → 386
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133189.1 Reference GRCz12tu Primary Assembly

    Range
    18858464..19129823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GMK0.1 GenPept UniProtKB/Swiss-Prot:Q6GMK0

Gene LinkOut

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