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ASTL astacin like metalloendopeptidase [ Homo sapiens (human) ]

Gene ID: 431705, updated on 19-Sep-2021

Summary

Official Symbol
ASTLprovided by HGNC
Official Full Name
astacin like metalloendopeptidaseprovided by HGNC
Primary source
HGNC:HGNC:31704
See related
Ensembl:ENSG00000188886 MIM:608860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAS1B
Expression
Biased expression in bone marrow (RPKM 1.1), skin (RPKM 0.2) and 10 other tissues See more
Orthologs
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Genomic context

See ASTL in Genome Data Viewer
Location:
2q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (96122817..96143059, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (96788557..96804241, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373494 Neighboring gene adrenoceptor alpha 2B Neighboring gene dual specificity phosphatase 2 Neighboring gene Sharpr-MPRA regulatory region 4518

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129843

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aspartic-type peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables glutamic-type peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in fertilization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of binding of sperm to zona pellucida ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of protein processing ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in prevention of polyspermy ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cortical granule ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
astacin-like metalloendopeptidase
Names
ZP2-proteinase
astacin-like metallo-endopeptidase (M12 family)
astacin-like metalloendopeptidase (M12 family)
oocyte astacin
ovastacin
sperm acrosomal SLLP1 binding
NP_001002036.3
XP_011509507.1
XP_011509508.1
XP_011509509.1
XP_011509510.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002036.4NP_001002036.3  astacin-like metalloendopeptidase precursor

    See identical proteins and their annotated locations for NP_001002036.3

    Status: VALIDATED

    Source sequence(s)
    AC012307
    Consensus CDS
    CCDS33249.1
    UniProtKB/Swiss-Prot
    Q6HA08
    Related
    ENSP00000343674.2, ENST00000342380.3
    Conserved Domains (2) summary
    pfam01400
    Location:92283
    Astacin; Astacin (Peptidase family M12A)
    cl00064
    Location:100281
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    96122817..96143059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511206.2XP_011509508.1  astacin-like metalloendopeptidase isoform X2

    Conserved Domains (2) summary
    pfam01400
    Location:93284
    Astacin; Astacin (Peptidase family M12A)
    cl00064
    Location:101282
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  2. XM_011511207.2XP_011509509.1  astacin-like metalloendopeptidase isoform X3

    Conserved Domains (2) summary
    pfam01400
    Location:97270
    Astacin; Astacin (Peptidase family M12A)
    cl00064
    Location:105268
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  3. XM_011511205.2XP_011509507.1  astacin-like metalloendopeptidase isoform X1

    Conserved Domains (2) summary
    pfam01400
    Location:97288
    Astacin; Astacin (Peptidase family M12A)
    cl00064
    Location:105286
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  4. XM_011511208.2XP_011509510.1  astacin-like metalloendopeptidase isoform X4

    Conserved Domains (2) summary
    smart00235
    Location:96239
    ZnMc; Zinc-dependent metalloprotease
    cl00064
    Location:105245
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
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