Format

Send to:

Choose Destination

RGS21 regulator of G protein signaling 21 [ Homo sapiens (human) ]

Gene ID: 431704, updated on 13-Mar-2020

Summary

Official Symbol
RGS21provided by HGNC
Official Full Name
regulator of G protein signaling 21provided by HGNC
Primary source
HGNC:HGNC:26839
See related
Ensembl:ENSG00000253148 MIM:612407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM, Nov 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See RGS21 in Genome Data Viewer
Location:
1q31.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (192316992..192367285)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (192286122..192336415)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371662 Neighboring gene ATP binding cassette subfamily E member 1 pseudogene Neighboring gene uncharacterized LOC105371664 Neighboring gene uncharacterized LOC107985241 Neighboring gene regulator of G protein signaling 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 21
Names
regulator of G-protein signalling 21

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039152.3NP_001034241.1  regulator of G-protein signaling 21

    See identical proteins and their annotated locations for NP_001034241.1

    Status: VALIDATED

    Source sequence(s)
    AL357566, AL390957, AY643711
    Consensus CDS
    CCDS41448.1
    UniProtKB/Swiss-Prot
    Q2M5E4
    Related
    ENSP00000428343.1, ENST00000417209.2
    Conserved Domains (1) summary
    cd08723
    Location:25135
    RGS_RGS21; Regulator of G protein signaling (RGS) domain found in the RGS21 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    192316992..192367285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center