MMP7 matrix metallopeptidase 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MMP7provided by HGNC
Official Full Name: matrix metallopeptidase 7provided by HGNC
Primary source: HGNC:HGNC:7174
See related: Ensembl:ENSG00000137673 MIM:178990
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MMP-7; MPSL1; PUMP-1
Summary: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]
Expression: Biased expression in gall bladder (RPKM 292.4), endometrium (RPKM 62.1) and 3 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 11q22.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	11	NC_000011.10 (102520508..102530753, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (102391239..102401478, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

EGFR-mediated matrix metalloproteinase-7 up-regulation promotes epithelial-mesenchymal transition via ERK1-AP1 axis during ovarian endometriosis progression.
Title: EGFR-mediated matrix metalloproteinase-7 up-regulation promotes epithelial-mesenchymal transition via ERK1-AP1 axis during ovarian endometriosis progression.
PRL-3 promotes glioblastoma progression by enhancing MMP7 through the ERK and JNK pathways.
Title: PRL-3 is a potential glioblastoma prognostic marker and promotes glioblastoma progression by enhancing MMP7 through the ERK and JNK pathways.
The results of this study suggest that the two MMP-7 polymorphisms, - A-181G and C-153T, do not play a major role in determining personal susceptibility to bladder cancer in Taiwan.
Title: Association of Matrix Metalloproteinase-7 Genotypes with the Risk of Bladder Cancer.
Results suggest a significant correlation of higher serum zinc levels with the diagnosis of prostate cancer. The polymorphism rs11568818 in MMP-7 gene was also associated with an increased prostate cancer risk in Poland.
Title: Association of zinc level and polymorphism in MMP-7 gene with prostate cancer in Polish population.
the results indicated that changes in MMP7 sensitivity, attributable to mutant AA, have the potential of identifying patients with distinct survival outcomes as well as patients with cancer specimen immune activity.
Title: MMP7 sensitivity of mutant ECM proteins: An indicator of melanoma survival rates and T-cell infiltration.
CTHRC1 serves as a pro-metastatic gene that contributes to NSCLC invasion and metastasis, which are mediated by upregulated MMP7 and MMP9 expression. Targeting CTHRC1 may be beneficial for inhibiting NSCLC metastasis.
Title: CTHRC1 induces non-small cell lung cancer (NSCLC) invasion through upregulating MMP-7/MMP-9.
no difference in the expression of MMP-7 and TIMP-1 in the endometrium in relation to hormone levels and menstrual cycle phases were observed
Title: Matrix metalloproteinases-2, -7 and tissue metalloproteinase inhibitor-1 expression in human endometrium.
MMP-7 A-181G may play an indirect role in determining personal susceptibility to Colorectal Cancer.
Title: The Contribution of <i>MMP-7</i> Genotypes to Colorectal Cancer Susceptibility in Taiwan.
Results provide evidence that MMP7 expression is regulated by leptin through ERK and JNK pathways to modulate cell invasion of ovarian neoplasm.
Title: Leptin induces matrix metalloproteinase 7 expression to promote ovarian cancer cell invasion by activating ERK and JNK pathways.
Absence of MMP-7 Promoter Polymorphisms is associated with Lung Cancer Susceptibility.
Title: The Contribution of <i>MMP-7</i> Promoter Polymorphisms to Taiwan Lung Cancer Susceptibility.

Submit: New GeneRIF Correction See all GeneRIFs (354)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120-treated vaginal epithelial cells show upregulation of matrix metallopeptidase 7 (MMP7) expression as compared to untreated control	PubMed
Tat	tat	HIV-1 Tat from AIDS patients with HIV-associated dementia upregulates MMP-2 and MMP-7 release and activation, leading to neurotoxicity	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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AGE/RAGE pathway, organism-specific biosystem (from WikiPathways)
AGE/RAGE pathway, organism-specific biosystemAdvanced glycation end products (AGEs) are heterogeneous group of non-enzymatic malliard reaction products of aldose sugar with proteins and lipids. Formation of AGEs is an indicator of one of the ma...
Activation of Matrix Metalloproteinases, organism-specific biosystem (from REACTOME)
Activation of Matrix Metalloproteinases, organism-specific biosystemThe matrix metalloproteinases (MMPs), previously known as matrixins, are classically known to be involved in the turnover of extracellular matrix (ECM) components. However, recent high throughput pro...
Assembly of collagen fibrils and other multimeric structures, organism-specific biosystem (from REACTOME)
Assembly of collagen fibrils and other multimeric structures, organism-specific biosystemCollagen trimers in triple-helical form, referred to as procollagen or collagen molecules, are exported from the ER and trafficked through the Golgi network before secretion into the extracellular sp...
Collagen degradation, organism-specific biosystem (from REACTOME)
Collagen degradation, organism-specific biosystemCollagen fibril diameter and spatial organisation are dependent on the species, tissue type and stage of development (Parry 1988). The lengths of collagen fibrils in mature tissues are largely unknow...
Collagen formation, organism-specific biosystem (from REACTOME)
Collagen formation, organism-specific biosystemCollagen is a family of at least 29 structural proteins derived from over 40 human genes (Myllyharju & Kivirikko 2004). It is the main component of connective tissue, and the most abundant protein in...
Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
Degradation of the extracellular matrix, organism-specific biosystemMatrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the...
Extracellular matrix organization, organism-specific biosystem (from REACTOME)
Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
Matrix Metalloproteinases, organism-specific biosystem (from WikiPathways)
Matrix Metalloproteinases, organism-specific biosystemMatrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzi...
Syndecan-1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
Syndecan-1-mediated signaling events, organism-specific biosystem
Syndecan-1-mediated signaling events
Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
Wnt signaling pathway, organism-specific biosystem (from KEGG)
Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt signaling pathway, conserved biosystem (from KEGG)
Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
p75(NTR)-mediated signaling, organism-specific biosystem
p75(NTR)-mediated signaling

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH46951 (e-PCR)
- UniSTS:27832

SGC35374 (e-PCR)
- UniSTS:27833

Homology

Homologs of the MMP7 gene: The MMP7 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, A.thaliana, and rice.
Orthologs from Annotation Pipeline: 187 organisms have orthologs with human gene MMP7
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
heparin binding	IEA Inferred from Electronic Annotation more info
metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
metalloendopeptidase activity	TAS Traceable Author Statement more info
metallopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
serine-type endopeptidase activity	TAS Traceable Author Statement more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
aging	IEA Inferred from Electronic Annotation more info
cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
collagen catabolic process	TAS Traceable Author Statement more info
estrous cycle	IEA Inferred from Electronic Annotation more info
extracellular matrix disassembly	TAS Traceable Author Statement more info
extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
maternal process involved in female pregnancy	IEA Inferred from Electronic Annotation more info
proteolysis	IDA Inferred from Direct Assay more info	PubMed
response to nutrient levels	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell surface	IEA Inferred from Electronic Annotation more info
extracellular exosome	HDA more info	PubMed
extracellular matrix	IEA Inferred from Electronic Annotation more info
extracellular region	TAS Traceable Author Statement more info
extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: matrilysin

Names: matrin; matrix metallopeptidase 7 (matrilysin, uterine); matrix metalloproteinase 7 (matrilysin, uterine); matrix metalloproteinase-7; pump-1 protease; uterine matrilysin; uterine metalloproteinase

NP_002414.1

EC 3.4.24.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002423.5 → NP_002414.1 matrilysin preproprotein

See identical proteins and their annotated locations for NP_002414.1

Status: REVIEWED

Source sequence(s)

BC003635, CB109660, X07819

Consensus CDS

CCDS8317.1

UniProtKB/Swiss-Prot

P09237

Related

ENSP00000260227.4, ENST00000260227.4

Conserved Domains (3) summary

cd04278
Location:103 → 259

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:103 → 259

Peptidase_M10; Matrixin

pfam01471
Location:31 → 82

PG_binding_1; Putative peptidoglycan binding domain