MMP7 matrix metallopeptidase 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MMP7provided by HGNC
Official Full Name: matrix metallopeptidase 7provided by HGNC
Primary source: HGNC:HGNC:7174
See related: Ensembl:ENSG00000137673 MIM:178990
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MMP-7; MPSL1; PUMP-1
Summary: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]
Expression: Biased expression in gall bladder (RPKM 292.4), endometrium (RPKM 62.1) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q22.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109.20201120	current	GRCh38.p13 (GCF_000001405.39)	11	NC_000011.10 (102520508..102530747, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (102391239..102401478, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Newcastle disease virus mediated apoptosis and migration inhibition of human oral cancer cells: A probable role of beta-catenin and matrix metalloproteinase-7.
Title: Newcastle disease virus mediated apoptosis and migration inhibition of human oral cancer cells: A probable role of β-catenin and matrix metalloproteinase-7.
Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage.
Title: Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage.
Elevated circulating metalloproteinase 7 predicts recurrent cardiovascular events in patients with carotid stenosis: a prospective cohort study.
Title: Elevated circulating metalloproteinase 7 predicts recurrent cardiovascular events in patients with carotid stenosis: a prospective cohort study.
Plasma levels of C-reactive protein, matrix metalloproteinase-7 and lipopolysaccharide-binding protein distinguish active pulmonary or extrapulmonary tuberculosis from uninfected controls in children.
Title: Plasma levels of C-reactive protein, matrix metalloproteinase-7 and lipopolysaccharide-binding protein distinguish active pulmonary or extrapulmonary tuberculosis from uninfected controls in children.
Up-regulation of MMP7 expression in the acute myeloid leukemia.High expression of MMP7 predicted poor prognosis in the acute myeloid leukemia.
Title: The prognostic value of matrix metalloproteinase-7 and matrix metalloproteinase-15 in acute myeloid leukemia.
we demonstrated that the recurrence potential in PNETs is characterized by the upregulation of genes related to ECM organization and cell adhesion. This study identified three genes-CLEC3, MMP7, and LCN2-that contribute to the prediction of postoperative recurrence of PNETs in clinical practice.
Title: CLEC3A, MMP7, and LCN2 as novel markers for predicting recurrence in resected G1 and G2 pancreatic neuroendocrine tumors.
A-181G and C-153T genotypes at MMP7 do not have a direct role in determining Taiwanese susceptibility to pterygium.
Title: The Association of <i>MMP7</i> Genotype With Pterygium.
urinary MMP-7, measured at time of acute kidney injury (AKI) clinical diagnosis, is a novel biomarker for predicting the progression of AKI after cardiac surgery
Title: Urinary Matrix Metalloproteinase-7 and Prediction of AKI Progression Post Cardiac Surgery.
To sum up, MMP-7 gene -181A/G polymorphism is not associated with the susceptibility to bladder cancer. However, subgroup analyses obtain significant association among the groups of smokers and drinkers.
Title: The association between matrix metalloproteinase-7 genetic variant and bladder cancer risk in a Chinese Han population.
The G allele of MMP7 A-181G may serve as an early predictor for gastric cancer risk in Taiwanese.
Title: The Association of <i>MMP7</i> Promoter Polymorphisms With Gastric Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (379)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120-treated vaginal epithelial cells show upregulation of matrix metallopeptidase 7 (MMP7) expression as compared to untreated control	PubMed
Tat	tat	HIV-1 Tat from AIDS patients with HIV-associated dementia upregulates MMP-2 and MMP-7 release and activation, leading to neurotoxicity	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH46951 (e-PCR)
- UniSTS:27832

SGC35374 (e-PCR)
- UniSTS:27833

Homology

Homologs of the MMP7 gene: The MMP7 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, A.thaliana, and rice.
Orthologs from Annotation Pipeline: 241 organisms have orthologs with human gene MMP7
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
heparin binding	IEA Inferred from Electronic Annotation more info
metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
metalloendopeptidase activity	TAS Traceable Author Statement more info
metallopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
serine-type endopeptidase activity	TAS Traceable Author Statement more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
aging	IEA Inferred from Electronic Annotation more info
cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
collagen catabolic process	TAS Traceable Author Statement more info
estrous cycle	IEA Inferred from Electronic Annotation more info
extracellular matrix disassembly	TAS Traceable Author Statement more info
extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
maternal process involved in female pregnancy	IEA Inferred from Electronic Annotation more info
membrane protein ectodomain proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
membrane protein intracellular domain proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
proteolysis	IDA Inferred from Direct Assay more info	PubMed
response to nutrient levels	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell surface	IEA Inferred from Electronic Annotation more info
extracellular exosome	HDA more info	PubMed
extracellular matrix	IEA Inferred from Electronic Annotation more info
extracellular region	TAS Traceable Author Statement more info
extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: matrilysin

Names: matrin; matrix metallopeptidase 7 (matrilysin, uterine); matrix metalloproteinase 7 (matrilysin, uterine); matrix metalloproteinase-7; pump-1 protease; uterine matrilysin; uterine metalloproteinase

NP_002414.1

EC 3.4.24.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002423.5 → NP_002414.1 matrilysin preproprotein

See identical proteins and their annotated locations for NP_002414.1

Status: REVIEWED

Source sequence(s)

BC003635, CB109660, X07819

Consensus CDS

CCDS8317.1

UniProtKB/Swiss-Prot

P09237

Related

ENSP00000260227.4, ENST00000260227.5

Conserved Domains (3) summary

cd04278
Location:103 → 259

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:103 → 259

Peptidase_M10; Matrixin

pfam01471
Location:31 → 82

PG_binding_1; Putative peptidoglycan binding domain