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Sld5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43166, updated on 4-Apr-2024

Summary

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Official Symbol
Sld5provided by FlyBase
Primary source
FLYBASE:FBgn0039403
Locus tag
Dmel_CG14549
See related
AllianceGenome:FB:FBgn0039403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0172774.61; CG14549; Dmel\CG14549; SLD5
Summary
Involved in mitotic cell cycle. Part of CMG complex and GINS complex. Orthologous to human GINS4 (GINS complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Sld5 in Genome Data Viewer
Location:
96F10-96F10; 3-89 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26055657..26056547, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21881379..21882269, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting 2 Neighboring gene Cytidine/uridine monophosphate kinase 1 Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class P Neighboring gene Threonyl-carbamoyl synthesis 6 Neighboring gene Ribosomal protein L34a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Sld5 is essential for normal cell cycle progression and maintenance of genomic integrity. Gouge CA, et al. Biochem Biophys Res Commun, 2010 Sep 10. PMID 20709026, Free PMC Article
  2. Comparing zinc finger nucleases and transcription activator-like effector nucleases for gene targeting in Drosophila. Beumer KJ, et al. G3 (Bethesda), 2013 Oct 3. PMID 23979928, Free PMC Article
  3. The mechanism of DNA unwinding by the eukaryotic replicative helicase. Burnham DR, et al. Nat Commun, 2019 May 14. PMID 31089141, Free PMC Article
  4. Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase. Kose HB, et al. Nat Commun, 2020 Jul 24. PMID 32709841, Free PMC Article
  5. DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome. Costa A, et al. Elife, 2014 Aug 12. PMID 25117490, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in DNA replication initiation IC
Inferred by Curator
more info
 PubMed 
involved_in DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CMG complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of GINS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GINS complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sld5
Names
CG14549-PA
Sld5-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26055657..26056547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143200.4 → NP_651457.1  Sld5 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651457.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3YD43, Q9VBI1
    Related
    FBpp0084348
    Conserved Domains (2) summary
    cd11711
    Location:38 → 156
    GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5
    cd21692
    Location:175 → 228
    GINS_B_Sld5; beta-strand (B) domain of GINS complex protein Sld5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6RAW_N.1
6RAX_N.1
6RAY_N.1
6RAZ_N.1
Q9VBI1 Q9VBI1

Gene LinkOut

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