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MME membrane metalloendopeptidase [ Homo sapiens (human) ]

Gene ID: 4311, updated on 9-Oct-2021

Summary

Official Symbol
MMEprovided by HGNC
Official Full Name
membrane metalloendopeptidaseprovided by HGNC
Primary source
HGNC:HGNC:7154
See related
Ensembl:ENSG00000196549 MIM:120520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEP; SFE; CD10; CALLA; CMT2T; SCA43
Summary
The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]
Expression
Biased expression in duodenum (RPKM 88.5), kidney (RPKM 83.7) and 8 other tissues See more
Orthologs
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Genomic context

See MME in Genome Data Viewer
Location:
3q25.2
Exon count:
30
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (155024202..155183729)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (154741991..154901518)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374170 Neighboring gene uncharacterized LOC105374171 Neighboring gene long intergenic non-protein coding RNA 1487 Neighboring gene small transmembrane regulator of ion transport 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of membrane metallo-endopeptidase (MME, CD10) expression as compared to untreated control PubMed
Tat tat HIV-1 Tat, which is found in the brains of patients with HIV-1 infection, inhibits the amyloid beta (Abeta)-degrading enzyme, neprilysin (NEP) PubMed
tat CD10/Nep inhibits HIV-1 Tat dimerization in Jurkat T-cells PubMed
Vif vif HIV-1 Vif upregulates the expression of membrane metallo-endopeptidase (MME) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126681, MGC126707, DKFZp686O16152

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cardiolipin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables endopeptidase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables exopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metalloendopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metallopeptidase activity EXP
Inferred from Experiment
more info
PubMed 
enables oligopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in amyloid-beta clearance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in amyloid-beta clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in amyloid-beta clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in amyloid-beta clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in amyloid-beta clearance by cellular catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in amyloid-beta clearance by cellular catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in amyloid-beta clearance by cellular catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in amyloid-beta metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in angiotensin maturation TAS
Traceable Author Statement
more info
 
involved_in cellular response to UV-A IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to UV-B IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in creatinine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in kidney development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in learning or memory IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in lung development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuropeptide processing IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peptide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in placenta development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neurogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in replicative senescence IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in axon IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection terminus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IGI
Inferred from Genetic Interaction
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in presynapse IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neprilysin
Names
atriopeptidase
common acute lymphocytic leukemia antigen
membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
membrane metallo-endopeptidase variant 1
membrane metallo-endopeptidase variant 2
neprilysin-390
neprilysin-411
neutral endopeptidase 24.11
skin fibroblast elastase
NP_000893.2
NP_001341571.1
NP_001341572.1
NP_001341573.1
NP_009218.2
NP_009219.2
NP_009220.2
XP_006713710.1
XP_011511158.1
XP_011511159.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051105.1 RefSeqGene

    Range
    60549..164606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000902.5NP_000893.2  neprilysin isoform a

    See identical proteins and their annotated locations for NP_000893.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains an alternate 5' UTR exon compared to variant 2b. Variants 1, 1bis, 2a, 2b, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC106724, BM151602, X07166
    Consensus CDS
    CCDS3172.1
    UniProtKB/Swiss-Prot
    P08473
    Related
    ENSP00000418525.1, ENST00000460393.6
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
  2. NM_001354642.2NP_001341571.1  neprilysin isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2b. Variants 1, 1bis, 2a, 2b, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC106724, AK291761
    Consensus CDS
    CCDS3172.1
    Related
    ENSP00000420389.1, ENST00000492661.5
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
  3. NM_001354643.1NP_001341572.1  neprilysin isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2b. Variants 1, 1bis, 2a, 2b, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC106724, AC117384, Y00811
    Consensus CDS
    CCDS3172.1
    Related
    ENSP00000417079.1, ENST00000493237.5
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
  4. NM_001354644.1NP_001341573.1  neprilysin isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 2b. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC117384, BC106070
    Consensus CDS
    CCDS87157.1
    Related
    ENSP00000372450.3, ENST00000382989.7
  5. NM_007287.4NP_009218.2  neprilysin isoform a

    See identical proteins and their annotated locations for NP_009218.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1bis) contains an alternate 5' UTR exon compared to variant 2b. Variants 1, 1bis, 2a, 2b, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC106724, AC117384, DB142029, X07166
    Consensus CDS
    CCDS3172.1
    UniProtKB/Swiss-Prot
    P08473
    Related
    ENSP00000502021.2, ENST00000675418.2
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
  6. NM_007288.3NP_009219.2  neprilysin isoform a

    See identical proteins and their annotated locations for NP_009219.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2a) contains an alternate 5' UTR exon, compared to variant 2b. Variants 1, 1bis, 2a, 2b, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC106724, AC117384
    Consensus CDS
    CCDS3172.1
    UniProtKB/Swiss-Prot
    P08473
    Related
    ENSP00000419653.1, ENST00000462745.5
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
  7. NM_007289.4NP_009220.2  neprilysin isoform a

    See identical proteins and their annotated locations for NP_009220.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2b) is the longest transcript and includes alternate exon 2b. Variants 1, 1bis, 2a, 2b, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC106724, AC117384
    Consensus CDS
    CCDS3172.1
    UniProtKB/Swiss-Prot
    P08473
    Related
    ENSP00000353679.2, ENST00000360490.7
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    155024202..155183729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713647.4XP_006713710.1  neprilysin isoform X1

    See identical proteins and their annotated locations for XP_006713710.1

    UniProtKB/Swiss-Prot
    P08473
    Related
    ENSP00000505211.1, ENST00000680057.1
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
  2. XM_011512856.2XP_011511158.1  neprilysin isoform X1

    See identical proteins and their annotated locations for XP_011511158.1

    UniProtKB/Swiss-Prot
    P08473
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
  3. XM_011512857.2XP_011511159.1  neprilysin isoform X1

    See identical proteins and their annotated locations for XP_011511159.1

    UniProtKB/Swiss-Prot
    P08473
    Related
    ENSP00000505690.1, ENST00000680282.1
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
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