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MME membrane metalloendopeptidase [ Homo sapiens (human) ]

Gene ID: 4311, updated on 14-Jun-2018
Official Symbol
MMEprovided by HGNC
Official Full Name
membrane metalloendopeptidaseprovided by HGNC
Primary source
HGNC:HGNC:7154
See related
Ensembl:ENSG00000196549 MIM:120520; Vega:OTTHUMG00000158455
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEP; SFE; CD10; CALLA; CMT2T; SCA43
Summary
The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]
Expression
Biased expression in duodenum (RPKM 88.5), kidney (RPKM 83.7) and 8 other tissues See more
Orthologs
See MME in Genome Data Viewer
Location:
3q25.2
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (155024124..155183729)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (154797436..154901518)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374170 Neighboring gene uncharacterized LOC105374171 Neighboring gene long intergenic non-protein coding RNA 1487 Neighboring gene DWARF open reading frame

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of membrane metallo-endopeptidase (MME, CD10) expression as compared to untreated control PubMed
Tat tat HIV-1 Tat, which is found in the brains of patients with HIV-1 infection, inhibits the amyloid beta (Abeta)-degrading enzyme, neprilysin (NEP) PubMed
tat CD10/Nep inhibits HIV-1 Tat dimerization in Jurkat T-cells PubMed
Vif vif HIV-1 Vif upregulates the expression of membrane metallo-endopeptidase (MME) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

  • Alzheimer's disease, organism-specific biosystem (from KEGG)
    Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimer's disease, conserved biosystem (from KEGG)
    Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
    Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystem (from REACTOME)
    Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystemAngiotensinogen, a prohormone, is synthesized and secreted mainly by the liver but also from other tissues (reviewed in Fyhrquist and Saijonmaa 2008, Cat and Touyz 2011). Renin, an aspartyl protease ...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
  • Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystem (from WikiPathways)
    Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystemPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) a cause of nephrotic syndrome in children and adolescents, as well as an important cause of end stage renal disease in adults. FSGS is ...
  • Protein digestion and absorption, organism-specific biosystem (from KEGG)
    Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Protein digestion and absorption, conserved biosystem (from KEGG)
    Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Renin-angiotensin system, organism-specific biosystem (from KEGG)
    Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Renin-angiotensin system, conserved biosystem (from KEGG)
    Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126681, MGC126707, DKFZp686O16152

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
exopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metalloendopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
metallopeptidase activity EXP
Inferred from Experiment
more info
PubMed 
peptide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
amyloid-beta clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
amyloid-beta metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
angiotensin maturation TAS
Traceable Author Statement
more info
 
cellular response to UV-A IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to UV-B IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
creatinine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
kidney development IEP
Inferred from Expression Pattern
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
peptide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
replicative senescence IEP
Inferred from Expression Pattern
more info
PubMed 
sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
brush border IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
neuron projection terminus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
neprilysin
Names
atriopeptidase
common acute lymphocytic leukemia antigen
membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
membrane metallo-endopeptidase variant 1
membrane metallo-endopeptidase variant 2
neprilysin-390
neprilysin-411
neutral endopeptidase 24.11
skin fibroblast elastase
NP_000893.2
NP_001341571.1
NP_001341572.1
NP_001341573.1
NP_009218.2
NP_009219.2
NP_009220.2
XP_006713710.1
XP_011511158.1
XP_011511159.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051105.1 RefSeqGene

    Range
    60524..164606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000902.3NP_000893.2  neprilysin isoform a

    See identical proteins and their annotated locations for NP_000893.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains an alternate 5' UTR exon compared to variant 2b. Variants 1, 1bis, 2a, 2b, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC106724, BM151602, X07166
    Consensus CDS
    CCDS3172.1
    UniProtKB/Swiss-Prot
    P08473
    Related
    ENSP00000418525.1, OTTHUMP00000212961, ENST00000460393.5, OTTHUMT00000351076
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  2. NM_001354642.1NP_001341571.1  neprilysin isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2b. Variants 1, 1bis, 2a, 2b, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC106724, AK291761
    Consensus CDS
    CCDS3172.1
    Related
    ENSP00000420389.1, ENST00000492661.5
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  3. NM_001354643.1NP_001341572.1  neprilysin isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2b. Variants 1, 1bis, 2a, 2b, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC106724, AC117384, Y00811
    Consensus CDS
    CCDS3172.1
    Related
    ENSP00000417079.1, ENST00000493237.5
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  4. NM_001354644.1NP_001341573.1  neprilysin isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 2b. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC117384, BC106070
    Consensus CDS
    CCDS87157.1
    Related
    ENSP00000372450.3, ENST00000382989.7
  5. NM_007287.2NP_009218.2  neprilysin isoform a

    See identical proteins and their annotated locations for NP_009218.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1bis) contains an alternate 5' UTR exon compared to variant 2b. Variants 1, 1bis, 2a, 2b, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC106724, DB142029, X07166
    Consensus CDS
    CCDS3172.1
    UniProtKB/Swiss-Prot
    P08473
    Related
    ENSP00000478173.1, ENST00000615825.1
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  6. NM_007288.3NP_009219.2  neprilysin isoform a

    See identical proteins and their annotated locations for NP_009219.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2a) contains an alternate 5' UTR exon, compared to variant 2b. Variants 1, 1bis, 2a, 2b, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC106724, AC117384
    Consensus CDS
    CCDS3172.1
    UniProtKB/Swiss-Prot
    P08473
    Related
    ENSP00000419653.1, OTTHUMP00000212963, ENST00000462745.5
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  7. NM_007289.3NP_009220.2  neprilysin isoform a

    See identical proteins and their annotated locations for NP_009220.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2b) is the longest transcript and includes alternate exon 2b. Variants 1, 1bis, 2a, 2b, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC106724, AC117384
    Consensus CDS
    CCDS3172.1
    UniProtKB/Swiss-Prot
    P08473
    Related
    ENSP00000353679.2, OTTHUMP00000212965, ENST00000360490.6
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    155024124..155183729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713647.4XP_006713710.1  neprilysin isoform X1

    See identical proteins and their annotated locations for XP_006713710.1

    UniProtKB/Swiss-Prot
    P08473
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  2. XM_011512856.2XP_011511158.1  neprilysin isoform X1

    See identical proteins and their annotated locations for XP_011511158.1

    UniProtKB/Swiss-Prot
    P08473
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  3. XM_011512857.2XP_011511159.1  neprilysin isoform X1

    See identical proteins and their annotated locations for XP_011511159.1

    UniProtKB/Swiss-Prot
    P08473
    Conserved Domains (1) summary
    cd08662
    Location:79748
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
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