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LpR2 Lipophorin receptor 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43105, updated on 8-Mar-2025

Summary

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Official Symbol
LpR2provided by FlyBase
Official Full Name
Lipophorin receptor 2provided by FlyBase
Primary source
FLYBASE:FBgn0051092
Locus tag
Dmel_CG31092
See related
AllianceGenome:FB:FBgn0051092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31092; CG4823; CG4834; Dmel\CG31092; lpr2; Lpr2; Lpr2-E
Summary
Enables lipoprotein particle binding activity. Involved in several processes, including mushroom body development; receptor-mediated endocytosis; and transport across blood-brain barrier. Located in plasma membrane. Is expressed in several structures, including adult head; embryonic central brain neurons; female germline cell; ganglia; and nephrocyte. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LRP8 (LDL receptor related protein 8); LDLR (low density lipoprotein receptor); and VLDLR (very low density lipoprotein receptor). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
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Genomic context

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See LpR2 in Genome Data Viewer
Location:
96E10-96F1; 3-89 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25698727..25740465, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21524449..21566187, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene Ribosomal protein L27 Neighboring gene Cardiolipin synthase Neighboring gene long non-coding RNA:CR46102 Neighboring gene Lipophorin receptor 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Different mechanisms for selective transport of fatty acids using a single class of lipoprotein in Drosophila. Matsuo N, et al. J Lipid Res, 2019 Jul. PMID 31085629, Free PMC Article
  2. Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions. Wang S, et al. J Biol Chem, 2018 May 11. PMID 29559555, Free PMC Article
  3. Lipophorin receptor 1 (LpR1) in Drosophila muscle influences life span by regulating mitochondrial aging. Kim AK, et al. Biochem Biophys Res Commun, 2021 Sep 3. PMID 34217014
  4. Lipophorin receptors regulate mushroom body development and complex behaviors in Drosophila. Rojo-Cortés F, et al. BMC Biol, 2022 Sep 7. PMID 36071487, Free PMC Article
  5. Drosophila lipophorin receptors mediate the uptake of neutral lipids in oocytes and imaginal disc cells by an endocytosis-independent mechanism. Parra-Peralbo E, et al. PLoS Genet, 2011 Feb 10. PMID 21347279, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. activity-induced isoform-specific upregulation of Drosophila lipophorin receptors LpR1 and LpR2, are reported.
    Title: Transcriptional Regulation of Lipophorin Receptors Supports Neuronal Adaptation to Chronic Elevations of Activity.
  2. Recruitment of apolipoprotein lipid transfer particle to cell membranes is mediated by Lpr2.
    Title: Drosophila Lipophorin Receptors Recruit the Lipoprotein LTP to the Plasma Membrane to Mediate Lipid Uptake.
  3. lipophorin receptor 1 and 2 (lpr1 and lpr2) are essential for the efficient uptake and accumulation of neutral lipids by oocytes and cells of the imaginal discs
    Title: Drosophila lipophorin receptors mediate the uptake of neutral lipids in oocytes and imaginal disc cells by an endocytosis-independent mechanism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c25734985-25725884 mobile_element_type = transposon:roo{}1421

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables lipoprotein particle binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lipid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transport across blood-brain barrier IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lipophorin receptor 2
Names
CG31092-PA
CG31092-PB
CG31092-PC
CG31092-PD
CG31092-PE
CG31092-PF
CG31092-PG
CG31092-PH
CG31092-PI
LpR2-PA
LpR2-PB
LpR2-PC
LpR2-PD
LpR2-PE
LpR2-PF
LpR2-PG
LpR2-PH
LpR2-PI
a2M-receptor-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25698727..25740465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104457.2 → NP_001097927.1  lipophorin receptor 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097927.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NN57
    Conserved Domains (1) summary
    smart00192
    Location:235 → 267
    LDLa; Low-density lipoprotein receptor domain class A

  2. NM_001104456.2 → NP_001097926.1  lipophorin receptor 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097926.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JRC4
    Conserved Domains (5) summary
    smart00192
    Location:235 → 267
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:717 → 760
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:564 → 594
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:277 → 313
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam14670
    Location:527 → 562
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. NM_001104459.2 → NP_001097929.1  lipophorin receptor 2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097929.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YTZ6
    Conserved Domains (5) summary
    smart00192
    Location:33 → 65
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:514 → 557
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:361 → 391
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:239 → 273
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam14670
    Location:324 → 359
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  4. NM_001104458.2 → NP_001097928.1  lipophorin receptor 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097928.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YU01
    Conserved Domains (5) summary
    smart00192
    Location:235 → 267
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:717 → 760
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:564 → 594
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:277 → 313
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam14670
    Location:527 → 562
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  5. NM_170239.4 → NP_733118.3  lipophorin receptor 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733118.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VBN2
    Conserved Domains (5) summary
    smart00192
    Location:235 → 267
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:716 → 759
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:563 → 593
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:441 → 475
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam14670
    Location:526 → 561
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  6. NM_001104460.2 → NP_001097930.1  lipophorin receptor 2, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097930.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JRC7
    Conserved Domains (5) summary
    smart00192
    Location:235 → 267
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:716 → 759
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:563 → 593
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:441 → 475
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam14670
    Location:526 → 561
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  7. NM_001276042.1 → NP_001262971.1  lipophorin receptor 2, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262971.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGZ9
    Conserved Domains (5) summary
    smart00192
    Location:33 → 65
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:515 → 558
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:362 → 392
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:75 → 111
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam14670
    Location:325 → 360
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  8. NM_001276041.1 → NP_001262970.1  lipophorin receptor 2, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262970.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH38
    Conserved Domains (5) summary
    smart00192
    Location:33 → 65
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:515 → 558
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:362 → 392
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:75 → 111
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam14670
    Location:325 → 360
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  9. NM_176565.2 → NP_788742.1  lipophorin receptor 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788742.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86B77
    Related
    FBpp0084302
    Conserved Domains (5) summary
    smart00192
    Location:33 → 65
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:514 → 557
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:361 → 391
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:239 → 273
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam14670
    Location:324 → 359
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGZ9 A0A0B4KGZ9
A0A0B4KH38 A0A0B4KH38
A8JRC4 A8JRC4
A8JRC7 A8JRC7
Q6NN57 Q6NN57
Q7YTZ6 Q7YTZ6
Q7YU01 Q7YU01
Q86B77 Q86B77
Q9VBN2 Q9VBN2

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