U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MLLT6 MLLT6, PHD finger containing [ Homo sapiens (human) ]

Gene ID: 4302, updated on 3-May-2025
Official Symbol
MLLT6provided by HGNC
Official Full Name
MLLT6, PHD finger containingprovided by HGNC
Primary source
HGNC:HGNC:7138
See related
Ensembl:ENSG00000275023 MIM:600328; AllianceGenome:HGNC:7138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AF17
Summary
Enables histone binding activity and nucleosome binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including renal potassium excretion; renal sodium excretion; and renal water absorption. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, May 2025]
Expression
Ubiquitous expression in spleen (RPKM 30.7), ovary (RPKM 26.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See MLLT6 in Genome Data Viewer
Location:
17q12
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (38705273..38729795)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (39568358..39592880)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36861526..36886048)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8107 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36829618-36830453 Neighboring gene Sharpr-MPRA regulatory region 4536 Neighboring gene elongin BC and polycomb repressive complex 2 associated protein Neighboring gene uncharacterized LOC105371763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36858367-36858898 Neighboring gene microRNA 4734 Neighboring gene uncharacterized LOC124903993 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36872979-36873638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36873639-36874298 Neighboring gene uncharacterized LOC105371762 Neighboring gene microRNA 4726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36881911-36882602 Neighboring gene control region 19 heart enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36887390-36887927 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36891176-36891703 Neighboring gene RNA, 5S ribosomal pseudogene 440 Neighboring gene CDGSH iron sulfur domain 3 Neighboring gene polycomb group ring finger 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36898365-36899265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36901628-36902393 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36902394-36903158 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36904187-36904722 Neighboring gene uncharacterized LOC100287808

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ23480

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein AF-17
Names
ALL1-fused gene from chromosome 17 protein
KMT2A-MLLT6 fusion protein
KMT2A/MLLT6 fusion
MLLT6, PHD finger domain containing
MLLT6/KMT2A fusion
Myeloid/lymphoid or mixed-lineage leukemia, translocated to, 6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
trithorax homolog

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005937.4NP_005928.2  protein AF-17

    See identical proteins and their annotated locations for NP_005928.2

    Status: VALIDATED

    Source sequence(s)
    AB209633, AC006449, KF456275
    Consensus CDS
    CCDS11327.1
    UniProtKB/Swiss-Prot
    P55198, Q59F28, Q96IU3, Q9H5F6, Q9UF49
    Related
    ENSP00000479910.1, ENST00000621332.5
    Conserved Domains (2) summary
    cd15574
    Location:754
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15709
    Location:61185
    ePHD_AF17; Extended PHD finger found in protein AF-17 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    38705273..38729795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    2740592..2765114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    39568358..39592880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)