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MLLT3 MLLT3, super elongation complex subunit [ Homo sapiens (human) ]

Gene ID: 4300, updated on 4-Nov-2018

Summary

Official Symbol
MLLT3provided by HGNC
Official Full Name
MLLT3, super elongation complex subunitprovided by HGNC
Primary source
HGNC:HGNC:7136
See related
Ensembl:ENSG00000171843 MIM:159558; Vega:OTTHUMG00000019650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AF9; YEATS3
Expression
Ubiquitous expression in thyroid (RPKM 6.2), colon (RPKM 4.6) and 23 other tissues See more
Orthologs

Genomic context

See MLLT3 in Genome Data Viewer
Location:
9p21.3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (20341665..20622543, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (20341663..20622514, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 24 member 2 Neighboring gene glutaredoxin 3 pseudogene 1 Neighboring gene survival of motor neuron 1, telomeric pseudogene Neighboring gene RNA, U4 small nuclear 26, pseudogene Neighboring gene microRNA 4473 Neighboring gene uncharacterized LOC107987052 Neighboring gene microRNA 4474 Neighboring gene ribosomal protein L7a pseudogene 48 Neighboring gene FOCAD antisense RNA 1 Neighboring gene focadhesin Neighboring gene microRNA 491

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat forms at least two distinct P-TEFb-containing complexes. Tatcom1 is composed of P-TEFb, AF9, ENL, ELL, AFF1, AFF4, and PAF1, presenting strong CTD-kinase activity, while Tatcom2 consists of 7SK, LARP7, and MEPCE with two molecules of Tat/P-TEFb PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ2035, FLJ46355

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
transcription elongation factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein AF-9
Names
ALL1-fused gene from chromosome 9 protein
YEATS domain-containing protein 3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein
myeloid/lymphoid or mixed-lineage leukemia; translocated to 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286691.1NP_001273620.1  protein AF-9 isoform b

    See identical proteins and their annotated locations for NP_001273620.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK301474, AL512635, AW451255, DC306929, DC345433
    Consensus CDS
    CCDS69579.1
    UniProtKB/Swiss-Prot
    P42568
    Related
    ENSP00000485996.1, OTTHUMP00000278746, ENST00000630269.2, OTTHUMT00000482950
    Conserved Domains (1) summary
    pfam03366
    Location:26106
    YEATS; YEATS family
  2. NM_004529.3NP_004520.2  protein AF-9 isoform a

    See identical proteins and their annotated locations for NP_004520.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL512635, AW451255, BC036089, BI550359, L13744
    Consensus CDS
    CCDS6494.1
    UniProtKB/Swiss-Prot
    P42568
    UniProtKB/TrEMBL
    A0A0S2Z448
    Related
    ENSP00000369695.4, OTTHUMP00000021127, ENST00000380338.8, OTTHUMT00000051872
    Conserved Domains (1) summary
    pfam03366
    Location:29109
    YEATS; YEATS family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    20341665..20622543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014726.2XP_016870215.1  protein AF-9 isoform X1

  2. XM_017014727.1XP_016870216.1  protein AF-9 isoform X2

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