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Hr96 Hormone receptor-like in 96 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42993, updated on 11-Apr-2024

Summary

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Official Symbol
Hr96provided by FlyBase
Official Full Name
Hormone receptor-like in 96provided by FlyBase
Primary source
FLYBASE:FBgn0015240
Locus tag
Dmel_CG11783
See related
AllianceGenome:FB:FBgn0015240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11783; dHR96; Dhr96; DHR96; Dmel\CG11783; HR96; NR1J1
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including lipid homeostasis; regulation of glycogen metabolic process; and regulation of transcription by RNA polymerase II. Is expressed in several structures, including embryonic/larval Malpighian tubule; embryonic/larval digestive system; and embryonic/larval fat body. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); lipid storage disease (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to several human genes including NR1I2 (nuclear receptor subfamily 1 group I member 2) and VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
96B16-96B17; 3-86 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25025235..25029351)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20850957..20855073)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tenectin Neighboring gene beta-4-galactosyltransferase 7 Neighboring gene ER membrane protein complex subunit 6 Neighboring gene Smg6 Neighboring gene YTH N6-methyladenosine RNA binding protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear receptor DHR96 acts as a sentinel for low cholesterol concentrations in Drosophila melanogaster. Bujold M, et al. Mol Cell Biol, 2010 Feb. PMID 19933845, Free PMC Article
  2. Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila. Afschar S, et al. Proc Natl Acad Sci U S A, 2016 Feb 2. PMID 26787908, Free PMC Article
  3. Nuclear hormone receptors: Roles of xenobiotic detoxification and sterol homeostasis in healthy aging. Hoffmann JM, et al. Crit Rev Biochem Mol Biol, 2015. PMID 26383043
  4. Coordination of triacylglycerol and cholesterol homeostasis by DHR96 and the Drosophila LipA homolog magro. Sieber MH, et al. Cell Metab, 2012 Jan 4. PMID 22197324, Free PMC Article
  5. Hormone receptor-like in 96 and Broad-Complex modulate phenobarbital induced transcription of cytochrome P450 CYP6D1 in Drosophila S2 cells. Lin GG, et al. Insect Mol Biol, 2011 Feb. PMID 21029232, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dhr96[1] mutation and maternal tudor[1] mutation increase life span and reduce the beneficial effects of mifepristone in mated female Drosophila.
    Title: Dhr96[1] mutation and maternal tudor[1] mutation increase life span and reduce the beneficial effects of mifepristone in mated female Drosophila.
  2. identified a nuclear hormone receptor, DHR96, as an essential mediator of the increased xenobiotic resistance of IIS mutant flies. However, the IIS mutants remained long-lived in the absence of DHR96 and the xenobiotic resistance that it conferred.
    Title: Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila.
  3. DHR96 coordinates lipid metabolism through direct regulation of LipA homolog magro proteins.
    Title: Coordination of triacylglycerol and cholesterol homeostasis by DHR96 and the Drosophila LipA homolog magro.
  4. DHR96 function is required in the midgut for the breakdown of dietary fat
    Title: The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila.
  5. DHR96 is activated when cellular cholesterol concentrations drop below a critical threshold in order to protect cells from severe cholesterol deprivation.
    Title: Nuclear receptor DHR96 acts as a sentinel for low cholesterol concentrations in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hormone receptor-like in 96
Names
CG11783-PA
Hr96-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25025235..25029351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079769.3 → NP_524493.1  hormone receptor-like in 96 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524493.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24143, Q9VBZ7
    Related
    FBpp0084131
    Conserved Domains (3) summary
    cd06929
    Location:523 → 702
    NR_LBD_F1; Ligand-binding domain of nuclear receptor family 1
    cd06966
    Location:5 → 98
    NR_DBD_CAR; DNA-binding domain of constitutive androstane receptor (CAR) is composed of two C4-type zinc fingers
    cl11397
    Location:462 → 573
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24143.1 Q24143

Gene LinkOut

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