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MLF1 myeloid leukemia factor 1 [ Homo sapiens (human) ]

Gene ID: 4291, updated on 11-Jun-2021

Summary

Official Symbol
MLF1provided by HGNC
Official Full Name
myeloid leukemia factor 1provided by HGNC
Primary source
HGNC:HGNC:7125
See related
Ensembl:ENSG00000178053 MIM:601402
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Expression
Biased expression in testis (RPKM 97.9), heart (RPKM 24.2) and 4 other tissues See more
Orthologs
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Genomic context

See MLF1 in Genome Data Viewer
Location:
3q25.32
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (158571194..158606456)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (158288983..158324245)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene arginine and serine rich coiled-coil 1 Neighboring gene long non-coding RNA uc.134 Neighboring gene MLF1 divergent transcript Neighboring gene methylthioadenosine phosphorylase pseudogene 1 Neighboring gene G elongation factor mitochondrial 1 Neighboring gene latexin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in myeloid progenitor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
myeloid leukemia factor 1
Names
myelodysplasia-myeloid leukemia factor 1
testis tissue sperm-binding protein Li 49e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027720.1 RefSeqGene

    Range
    5031..40293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1388

mRNA and Protein(s)

  1. NM_001130156.3NP_001123628.1  myeloid leukemia factor 1 isoform 2

    See identical proteins and their annotated locations for NP_001123628.1

    Status: REVIEWED

    Source sequence(s)
    AY848702, BX647666, DB455518
    Consensus CDS
    CCDS46945.1
    UniProtKB/Swiss-Prot
    P58340
    UniProtKB/TrEMBL
    A0A140VKD2, Q5HYH4
    Related
    ENSP00000352025.5, ENST00000359117.9
    Conserved Domains (1) summary
    pfam10248
    Location:1177
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  2. NM_001130157.3NP_001123629.1  myeloid leukemia factor 1 isoform 2

    See identical proteins and their annotated locations for NP_001123629.1

    Status: REVIEWED

    Source sequence(s)
    AC025033, AY848701, BX647666, DB455518
    Consensus CDS
    CCDS46945.1
    UniProtKB/Swiss-Prot
    P58340
    UniProtKB/TrEMBL
    A0A140VKD2, Q2TLE4, Q5HYH4
    Related
    ENSP00000417835.1, ENST00000484955.5
    Conserved Domains (1) summary
    pfam10248
    Location:1177
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  3. NM_001195432.4NP_001182361.2  myeloid leukemia factor 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC106707
    Consensus CDS
    CCDS56286.1
    Related
    ENSP00000417777.3, ENST00000478894.7
    Conserved Domains (1) summary
    pfam10248
    Location:1192
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  4. NM_001195433.2NP_001182362.1  myeloid leukemia factor 1 isoform 4

    See identical proteins and their annotated locations for NP_001182362.1

    Status: REVIEWED

    Source sequence(s)
    AY848700, BX647666, DB455518
    Consensus CDS
    CCDS56288.1
    UniProtKB/Swiss-Prot
    P58340
    UniProtKB/TrEMBL
    Q5HYH4
    Related
    ENSP00000418595.1, ENST00000469452.5
    Conserved Domains (1) summary
    pfam10248
    Location:2134
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  5. NM_001195434.2NP_001182363.1  myeloid leukemia factor 1 isoform 5

    See identical proteins and their annotated locations for NP_001182363.1

    Status: REVIEWED

    Source sequence(s)
    AK056948, BX647666
    Consensus CDS
    CCDS56287.1
    UniProtKB/Swiss-Prot
    P58340
    UniProtKB/TrEMBL
    Q5HYH4
    Related
    ENSP00000420134.1, ENST00000471745.5
    Conserved Domains (1) summary
    pfam10248
    Location:1192
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  6. NM_001369781.1NP_001356710.1  myeloid leukemia factor 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC106707
    Related
    ENSP00000483337.2, ENST00000619577.5
    Conserved Domains (1) summary
    pfam10248
    Location:30157
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  7. NM_001369782.1NP_001356711.1  myeloid leukemia factor 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC106707, KU178188
    Related
    ENSP00000420410.2, ENST00000491767.6
    Conserved Domains (1) summary
    pfam10248
    Location:1128
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  8. NM_001369783.1NP_001356712.1  myeloid leukemia factor 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC106707, KU178187
    Related
    ENSP00000417278.2, ENST00000466246.7
    Conserved Domains (1) summary
    pfam10248
    Location:90217
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  9. NM_001369784.1NP_001356713.1  myeloid leukemia factor 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC106707
    Conserved Domains (1) summary
    pfam10248
    Location:1177
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  10. NM_001369785.1NP_001356714.1  myeloid leukemia factor 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC106707
    Related
    ENSP00000419637.2, ENST00000477042.6
    Conserved Domains (1) summary
    pfam10248
    Location:1192
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  11. NM_001378845.1NP_001365774.1  myeloid leukemia factor 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC106707
    Conserved Domains (1) summary
    pfam10248
    Location:26202
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  12. NM_001378846.1NP_001365775.1  myeloid leukemia factor 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC106707
    Conserved Domains (1) summary
    pfam10248
    Location:1192
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  13. NM_001378847.1NP_001365776.1  myeloid leukemia factor 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC106707
    Related
    ENSP00000499162.1, ENST00000651984.1
    Conserved Domains (1) summary
    pfam10248
    Location:1177
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  14. NM_001378848.1NP_001365777.1  myeloid leukemia factor 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC106707
    Related
    ENSP00000498363.1, ENST00000651874.1
    Conserved Domains (1) summary
    pfam10248
    Location:1177
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  15. NM_001378850.1NP_001365779.1  myeloid leukemia factor 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC106707
    Conserved Domains (1) summary
    pfam10248
    Location:1177
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  16. NM_001378851.1NP_001365780.1  myeloid leukemia factor 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC106707
    Related
    ENSP00000419636.2, ENST00000498592.6
    Conserved Domains (1) summary
    pfam10248
    Location:37174
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  17. NM_001378852.1NP_001365781.1  myeloid leukemia factor 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC106707
    Related
    ENSP00000498915.1, ENST00000650753.1
    Conserved Domains (1) summary
    pfam10248
    Location:26189
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  18. NM_001378853.1NP_001365782.1  myeloid leukemia factor 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC106707
    Conserved Domains (1) summary
    pfam10248
    Location:1177
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  19. NM_001378855.1NP_001365784.1  myeloid leukemia factor 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC106707
    Conserved Domains (1) summary
    pfam10248
    Location:1164
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  20. NM_022443.5NP_071888.1  myeloid leukemia factor 1 isoform 1

    See identical proteins and their annotated locations for NP_071888.1

    Status: REVIEWED

    Source sequence(s)
    AA707847, AC025033, AK315402, KU178186
    Consensus CDS
    CCDS3182.1
    UniProtKB/Swiss-Prot
    P58340
    UniProtKB/TrEMBL
    A0A0S2Z4U8, B2RD48, Q5HYH4
    Related
    ENSP00000348157.5, ENST00000355893.11
    Conserved Domains (1) summary
    pfam10248
    Location:75202
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    158571194..158606456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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