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DPYD dihydropyrimidine dehydrogenase [ Gallus gallus (chicken) ]

Gene ID: 429083, updated on 30-May-2026
Official Symbol
DPYDprovided by CGNC
Official Full Name
dihydropyrimidine dehydrogenaseprovided by CGNC
Primary source
CGNC:4104
See related
Ensembl:ENSGALG00010024191
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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Try the new Transcripts and proteins table
See DPYD in Genome Data Viewer
Location:
chromosome: 8
Exon count:
28
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 8 NC_052539.1 (12309480..12626349)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 8 NC_052580.1 (12317324..12633486)

Chromosome 8 - NC_052539.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101750449 Neighboring gene uncharacterized LOC121113423 Neighboring gene microRNA 137 Neighboring gene uncharacterized LOC101750667 Neighboring gene uncharacterized LOC124418142 Neighboring gene polypyrimidine tract binding protein 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Comparative metabolic pathway analysis with special reference to nucleotide metabolism-related genes in chicken primordial germ cells. Rengaraj D, et al. Theriogenology, 2013 Jan 1. PMID 23102846
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. According to microarray and qRT-PCR analyses, the nucleotide metabolism-related gene DPYD was more highly expressed in the chicken primordial germ cells than that of stage X blastoderms.
    Title: Comparative metabolic pathway analysis with special reference to nucleotide metabolism-related genes in chicken primordial germ cells.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables dihydropyrimidine dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables uracil binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in thymine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in uracil catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
dihydropyrimidine dehydrogenase [NADP(+)]
XP_025008718.1
XP_025008719.1
XP_040533703.1
XP_040533704.1
XP_040533705.1
XP_040533706.1
XP_040533707.1
XP_040560906.1
XP_040560907.1
XP_426639.3

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    12309480..12626349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025152950.3 → XP_025008718.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X3

    UniProtKB/TrEMBL
    E1C4J1
    Conserved Domains (3) summary
    cd02940
    Location:456 → 758
    DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
    pfam14697
    Location:883 → 941
    Fer4_21; 4Fe-4S dicluster domain
    cl40752
    Location:2 → 437
    GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

  2. XM_025152951.3 → XP_025008719.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZWJ2
    Conserved Domains (3) summary
    cd02940
    Location:532 → 834
    DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
    pfam14697
    Location:959 → 1017
    Fer4_21; 4Fe-4S dicluster domain
    cl40752
    Location:53 → 513
    GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

  3. XM_426639.8 → XP_426639.3  dihydropyrimidine dehydrogenase [NADP(+)] isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZWJ2
    Related
    ENSGALP00010036012.1, ENSGALT00010059048.1
    Conserved Domains (3) summary
    cd02940
    Location:532 → 834
    DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
    pfam14697
    Location:946 → 1004
    Fer4_21; 4Fe-4S dicluster domain
    cl40752
    Location:53 → 513
    GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

  4. XM_040704972.2 → XP_040560906.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZRA5
    Related
    ENSGALP00010035989.1, ENSGALT00010059025.1
    Conserved Domains (2) summary
    cd02940
    Location:532 → 814
    DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
    cl40752
    Location:53 → 513
    GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

  5. XM_040704973.2 → XP_040560907.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X5

    Conserved Domains (1) summary
    cl40752
    Location:53 → 508
    GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

RNA

  1. XR_003076346.3 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    12317324..12633486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040677771.2 → XP_040533705.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X3

    UniProtKB/TrEMBL
    E1C4J1
    Conserved Domains (3) summary
    cd02940
    Location:456 → 758
    DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
    pfam14697
    Location:883 → 941
    Fer4_21; 4Fe-4S dicluster domain
    cl40752
    Location:2 → 437
    GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

  2. XM_040677769.2 → XP_040533703.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZWJ2
    Conserved Domains (3) summary
    cd02940
    Location:532 → 834
    DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
    pfam14697
    Location:959 → 1017
    Fer4_21; 4Fe-4S dicluster domain
    cl40752
    Location:53 → 513
    GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

  3. XM_040677770.2 → XP_040533704.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZWJ2
    Conserved Domains (3) summary
    cd02940
    Location:532 → 834
    DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
    pfam14697
    Location:946 → 1004
    Fer4_21; 4Fe-4S dicluster domain
    cl40752
    Location:53 → 513
    GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

  4. XM_040677772.2 → XP_040533706.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZRA5
    Conserved Domains (2) summary
    cd02940
    Location:532 → 814
    DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
    cl40752
    Location:53 → 513
    GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

  5. XM_040677773.2 → XP_040533707.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X5

    Conserved Domains (1) summary
    cl40752
    Location:53 → 508
    GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

RNA

  1. XR_005852171.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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