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Rrp5 Ribosomal RNA Processing 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42899, updated on 8-Mar-2025

Summary

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Official Symbol
Rrp5provided by FlyBase
Official Full Name
Ribosomal RNA Processing 5provided by FlyBase
Primary source
FLYBASE:FBgn0039182
Locus tag
Dmel_CG5728
See related
AllianceGenome:FB:FBgn0039182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5728; Dmel\CG5728
Summary
Predicted to enable RNA binding activity. Involved in rRNA processing. Is active in nucleolus. Is expressed in several structures, including Malpighian tubule primordium; adult fat body; adult head; embryonic/larval midgut primordium; and larval somatic muscle cell. Orthologous to human PDCD11 (programmed cell death 11). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
all
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Genomic context

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See Rrp5 in Genome Data Viewer
Location:
95F12-95F13; 3-84 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24328455..24333316, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20154177..20159038, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Nuclear polyadenosine RNA-binding 2 Neighboring gene antisense RNA:CR46093 Neighboring gene BRWD3 Neighboring gene Dis3 Neighboring gene uncharacterized protein Neighboring gene mir-1015 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The DEAD-Box Protein Rok1 Coordinates Ribosomal RNA Processing in Association with Rrp5 in Drosophila. Chen J, et al. Int J Mol Sci, 2022 May 19. PMID 35628496, Free PMC Article
  2. Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Le Thomas A, et al. Genes Dev, 2013 Feb 15. PMID 23392610, Free PMC Article
  3. Cell Cycle Kinase Polo Is Controlled by a Widespread 3' Untranslated Region Regulatory Sequence in Drosophila melanogaster. Oliveira MS, et al. Mol Cell Biol, 2019 Aug 1. PMID 31085682, Free PMC Article
  4. Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway. Grewal SS, et al. J Cell Biol, 2007 Dec 17. PMID 18086911, Free PMC Article
  5. DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation. Pek JW, et al. Proc Natl Acad Sci U S A, 2011 Jul 19. PMID 21730191, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in rRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ribosomal RNA processing 5
Names
CG5728-PA
Rrp5-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24328455..24333316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142988.4 → NP_651245.1  ribosomal RNA processing 5 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651245.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95RD5, Q9VC94
    Related
    FBpp0084016
    Conserved Domains (5) summary
    smart00316
    Location:530 → 591
    S1; Ribosomal protein S1-like RNA-binding domain
    COG0457
    Location:1170 → 1403
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    cd05693
    Location:71 → 165
    S1_Rrp5_repeat_hs1_sc1; S1_Rrp5_repeat_hs1_sc1: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats ...
    sd00006
    Location:1320 → 1350
    TPR; TPR repeat [structural motif]
    cl09927
    Location:172 → 243
    S1_like; S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VC94 Q9VC94
Q9VC94.2

Gene LinkOut

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