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crb crumbs [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42896, updated on 26-Aug-2021

Summary

Official Symbol
crbprovided by FlyBase
Official Full Name
crumbsprovided by FlyBase
Primary source
FLYBASE:FBgn0259685
Locus tag
Dmel_CG6383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0509/20; 1384/04; CG6383; Crb; CRB; Crbs; crumb; Crumbs; CT19912; DmCrb; Dmel\CG6383; far; l(3)07207; l(3)j1B5; l(3)S050920; l(3)S058104
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Genomic context

See crb in Genome Data Viewer
Location:
95F10-95F11; 3-84 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24295078..24314541)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20120800..20140263)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Uridine-cytidine kinase Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46093 Neighboring gene Nuclear polyadenosine RNA-binding 2 Neighboring gene BRWD3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables spectrin binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in Malpighian tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adherens junction organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in amnioserosa maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apical constriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apical protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apical protein localization IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in assembly of apicomedial cortex actomyosin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell morphogenesis involved in Malpighian tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal closure, amnioserosa morphology change IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of apical/basal cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of polarity of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of polarity of follicular epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in liquid clearance, open tracheal system IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in maintenance of apical/basal cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hippo signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rhabdomere development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rhabdomere morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in trachea development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wing disc dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in zonula adherens assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in zonula adherens maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
crumbs
Names
CG6383-PA
CG6383-PB
CG6383-PC
CG6383-PD
crb-PA
crb-PB
crb-PC
crb-PD
fat rhabdomere
fat rhabdomeres
lethal (3) 07207

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24295078..24314541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260355.2NP_001247284.1  crumbs, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247284.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7R8
    Related
    FBpp0293268, FBtr0304726
    Conserved Domains (5) summary
    cd00054
    Location:792828
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:91228
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:466495
    EGF; EGF-like domain
    pfam00054
    Location:11551290
    Laminin_G_1; Laminin G domain
    pfam02210
    Location:16921828
    Laminin_G_2; Laminin G domain
  2. NM_001275980.1NP_001262909.1  crumbs, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262909.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHS1
    Related
    FBpp0306945, FBtr0334925
    Conserved Domains (5) summary
    cd00054
    Location:959995
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:91228
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:466495
    EGF; EGF-like domain
    pfam00054
    Location:11051240
    Laminin_G_1; Laminin G domain
    pfam02210
    Location:16421778
    Laminin_G_2; Laminin G domain
  3. NM_001043286.2NP_001036751.1  crumbs, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036751.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P10040
    Related
    FBpp0110307, FBtr0111008
    Conserved Domains (5) summary
    cd00054
    Location:728764
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:91228
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:466495
    EGF; EGF-like domain
    pfam00054
    Location:10911226
    Laminin_G_1; Laminin G domain
    pfam02210
    Location:16281764
    Laminin_G_2; Laminin G domain
  4. NM_079756.3NP_524480.2  crumbs, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524480.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P10040
    Related
    FBpp0083987, FBtr0084603
    Conserved Domains (5) summary
    cd00054
    Location:685721
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:91228
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:466495
    EGF; EGF-like domain
    pfam00054
    Location:10481183
    Laminin_G_1; Laminin G domain
    pfam02210
    Location:15851721
    Laminin_G_2; Laminin G domain
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