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MKI67 marker of proliferation Ki-67 [ Homo sapiens (human) ]

Gene ID: 4288, updated on 18-Nov-2018

Summary

Official Symbol
MKI67provided by HGNC
Official Full Name
marker of proliferation Ki-67provided by HGNC
Primary source
HGNC:HGNC:7107
See related
Ensembl:ENSG00000148773 MIM:176741; Vega:OTTHUMG00000019255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIA; MIB-; MIB-1; PPP1R105
Summary
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]
Expression
Biased expression in bone marrow (RPKM 18.5), lymph node (RPKM 8.4) and 12 other tissues See more
Orthologs

Genomic context

See MKI67 in Genome Data Viewer
Location:
10q26.2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (128096659..128126405, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (129894923..129924468, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene clarin 3 Neighboring gene protein tyrosine phosphatase, receptor type E Neighboring gene lncRNA antisense to PTPRE protein-coding gene Neighboring gene long intergenic non-protein coding RNA 1163 Neighboring gene VISTA enhancer hs737

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 increases MK167 (Ki67) expression and inversely correlates with PRDM1 (BLIMP1) expression in activated B cells from HIV-1-infected treatment naive individuals PubMed
HIV-1 infection decreases MKI67 expression in hippocampal sections of brain autopsy tissue PubMed
HIV-1 upregulates MKI67(Ki-67) in CD4+ and CD8+ T lymphocytes as observed in clinical samples collected from HIV-1 infected patients PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Podocyte-specific expression of HIV-1 Nef induces loss of synaptopodin and WT1, and expression of Ki-67 in podocytes, which is essential for the dedifferentiation and proliferation of podocytes in HIV-associated nephropathy PubMed
Pr55(Gag) gag Cellular biotinylated marker of proliferation Ki-67 (MKI67) protein is incorporated into HIV-1 Gag virus-like particles PubMed
gag HIV-1 Gag co-localizes with Ki-67 in germinal center of HIV-1 infected patients PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
NOT cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of chromosome segregation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proliferation marker protein Ki-67
Names
antigen Ki67
antigen identified by monoclonal antibody Ki-67
proliferation-related Ki-67 antigen
protein phosphatase 1, regulatory subunit 105

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047061.1 RefSeqGene

    Range
    5160..34705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145966.1NP_001139438.1  proliferation marker protein Ki-67 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL355529, AL390236, BU632619, BU855841, X65551
    Consensus CDS
    CCDS53588.1
    UniProtKB/Swiss-Prot
    P46013
    Related
    ENSP00000357642.3, OTTHUMP00000020740, ENST00000368653.7, OTTHUMT00000051000
    Conserved Domains (4) summary
    COG1716
    Location:11119
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:898
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam08065
    Location:643752
    K167R; K167R (NUC007) repeat
    pfam15276
    Location:143185
    PP1_bind; Protein phosphatase 1 binding
  2. NM_002417.4NP_002408.3  proliferation marker protein Ki-67 isoform 1

    See identical proteins and their annotated locations for NP_002408.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL355529, AL390236, BU632619, BU855841, X65550
    Consensus CDS
    CCDS7659.1
    UniProtKB/Swiss-Prot
    P46013
    Related
    ENSP00000357643.3, OTTHUMP00000020739, ENST00000368654.7, OTTHUMT00000050999
    Conserved Domains (4) summary
    COG1716
    Location:11119
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:898
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam08065
    Location:10031112
    K167R; K167R (NUC007) repeat
    pfam15276
    Location:503545
    PP1_bind; Protein phosphatase 1 binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    128096659..128126405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539818.2XP_011538120.1  proliferation marker protein Ki-67 isoform X1

    Conserved Domains (2) summary
    pfam08065
    Location:659768
    K167R; K167R (NUC007) repeat
    pfam15276
    Location:159201
    PP1_bind; Protein phosphatase 1 binding
  2. XM_006717864.3XP_006717927.2  proliferation marker protein Ki-67 isoform X2

    Conserved Domains (1) summary
    pfam08065
    Location:229338
    K167R; K167R (NUC007) repeat
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