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MKI67 marker of proliferation Ki-67 [ Homo sapiens (human) ]

Gene ID: 4288, updated on 5-May-2024

Summary

Official Symbol
MKI67provided by HGNC
Official Full Name
marker of proliferation Ki-67provided by HGNC
Primary source
HGNC:HGNC:7107
See related
Ensembl:ENSG00000148773 MIM:176741; AllianceGenome:HGNC:7107
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIA; MIB-; MIB-1; PPP1R105
Summary
Enables protein C-terminus binding activity. Involved in regulation of chromosome segregation and regulation of mitotic nuclear division. Located in chromosome; nuclear body; and nucleolus. Colocalizes with condensed chromosome. Implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Biomarker of several diseases, including Barrett's esophagus; autoimmune disease of musculoskeletal system (multiple); endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and interstitial cystitis. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 18.5), lymph node (RPKM 8.4) and 12 other tissues See more
Orthologs
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Genomic context

See MKI67 in Genome Data Viewer
Location:
10q26.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (128096659..128126423, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (128995212..129024955, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (129894923..129924687, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129733337-129734076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129775634-129776134 Neighboring gene protein tyrosine phosphatase receptor type E Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129820967-129821467 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129843223-129843724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129843725-129844224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4198 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:129860232-129861431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129861772-129862370 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:129867603-129867800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129876659-129877158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129876157-129876658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129889651-129890152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129890153-129890652 Neighboring gene lncRNA antisense to PTPRE protein-coding gene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2933 Neighboring gene NANOG hESC enhancer GRCh37_chr10:129963700-129964282 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:129970982-129972181 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:129999872-130000380 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:130000381-130000888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130007752-130008313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130109218-130109718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130109719-130110219 Neighboring gene uncharacterized LOC124902558 Neighboring gene long intergenic non-protein coding RNA 1163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130184885-130185386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130232943-130233444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130238232-130238732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130281351-130281852 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130281853-130282352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:130317555-130318446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:130318447-130319337 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:130339525-130340200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130365840-130366340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130366341-130366841 Neighboring gene VISTA enhancer hs737 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:130424650-130424847 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:130427109-130428308 Neighboring gene uncharacterized LOC105378554

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 increases MK167 (Ki67) expression and inversely correlates with PRDM1 (BLIMP1) expression in activated B cells from HIV-1-infected treatment naive individuals PubMed
HIV-1 infection decreases MKI67 expression in hippocampal sections of brain autopsy tissue PubMed
HIV-1 upregulates MKI67(Ki-67) in CD4+ and CD8+ T lymphocytes as observed in clinical samples collected from HIV-1 infected patients PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Podocyte-specific expression of HIV-1 Nef induces loss of synaptopodin and WT1, and expression of Ki-67 in podocytes, which is essential for the dedifferentiation and proliferation of podocytes in HIV-associated nephropathy PubMed
Pr55(Gag) gag Cellular biotinylated marker of proliferation Ki-67 (MKI67) protein is incorporated into HIV-1 Gag virus-like particles PubMed
gag HIV-1 Gag co-localizes with Ki-67 in germinal center of HIV-1 infected patients PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NOT involved_in cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of chromosome segregation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mitotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromosome IDA
Inferred from Direct Assay
more info
 
colocalizes_with condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proliferation marker protein Ki-67
Names
Molecular Immunology Borstel antibody 1
antigen Ki67
antigen identified by monoclonal antibody Ki-67
proliferation-related Ki-67 antigen
protein phosphatase 1, regulatory subunit 105

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047061.1 RefSeqGene

    Range
    4941..34705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145966.2NP_001139438.1  proliferation marker protein Ki-67 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL355529, AL390236, BU632619, BU855841, X65551
    Consensus CDS
    CCDS53588.1
    UniProtKB/Swiss-Prot
    P46013
    Related
    ENSP00000357642.3, ENST00000368653.7
    Conserved Domains (4) summary
    COG1716
    Location:11119
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:898
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam08065
    Location:643752
    K167R; K167R (NUC007) repeat
    pfam15276
    Location:143185
    PP1_bind; Protein phosphatase 1 binding
  2. NM_002417.5NP_002408.3  proliferation marker protein Ki-67 isoform 1

    See identical proteins and their annotated locations for NP_002408.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL355529, AL390236, BU632619, BU855841, X65550
    Consensus CDS
    CCDS7659.1
    UniProtKB/Swiss-Prot
    P46013, Q5VWH2
    Related
    ENSP00000357643.3, ENST00000368654.8
    Conserved Domains (4) summary
    COG1716
    Location:11119
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:898
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam08065
    Location:10031112
    K167R; K167R (NUC007) repeat
    pfam15276
    Location:503545
    PP1_bind; Protein phosphatase 1 binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    128096659..128126423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539818.3XP_011538120.1  proliferation marker protein Ki-67 isoform X2

    Conserved Domains (2) summary
    pfam08065
    Location:659768
    K167R; K167R (NUC007) repeat
    pfam15276
    Location:159201
    PP1_bind; Protein phosphatase 1 binding
  2. XM_006717864.4XP_006717927.2  proliferation marker protein Ki-67 isoform X1

    Conserved Domains (1) summary
    pfam08065
    Location:229338
    K167R; K167R (NUC007) repeat

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    128995212..129024955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365949.1XP_054221924.1  proliferation marker protein Ki-67 isoform X1