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ANXA5 annexin A5 [ Gallus gallus (chicken) ]

Gene ID: 428767, updated on 5-Sep-2025
Official Symbol
ANXA5provided by CGNC
Official Full Name
annexin A5provided by CGNC
Primary source
CGNC:9009
See related
Ensembl:ENSGALG00010005260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
ANX5; CBP-I; CPB-I; PAP-I
Orthologs
human mouse all
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See ANXA5 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
20
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (53469183..53512313)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (53471484..53515093)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene cyclin A2 Neighboring gene exosome component 9 Neighboring gene uncharacterized LOC124417902 Neighboring gene pyroglutamylated RFamide peptide receptor

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Key role of the N-terminus of chicken annexin A5 in vesicle aggregation. Turnay J, et al. Protein Sci, 2009 May. PMID 19388055, Free PMC Article
  2. Annexin V and terminal differentiation of growth plate chondrocytes. Wang W, et al. Exp Cell Res, 2005 Apr 15. PMID 15777796
  3. Isolation, characterization and localization of annexin V from chicken liver. Boustead CM, et al. Biochem J, 1993 Apr 15. PMID 8484740, Free PMC Article
  4. Structure of chicken annexin V at 2.25-A resolution. Bewley MC, et al. Biochemistry, 1993 Apr 20. PMID 8471604
  5. Structure of the gene encoding anchorin CII (chick annexin V). Fernández MP, et al. Gene, 1994 Apr 20. PMID 8163186

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study shows annexin A5 induces aggregation of vesicles containing acidic phospholipids even at low protein and/or calcium concentration by establishment of protein dimers; experiments show ability to aggregate vesicles mainly resides in the N-terminus
    Title: Key role of the N-terminus of chicken annexin A5 in vesicle aggregation.
  2. Overexpression of annexin V is sufficient to stimulate these terminal differentiation events in growth plate chondrocytes in the chick embryo.
    Title: Annexin V and terminal differentiation of growth plate chondrocytes.
  3. binding of annexin V to active PKCalpha stimulates apoptotic events in growth plate chondrocytes and binding of annexin V to beta5 integrin controls these interactions and ultimately apoptosis
    Title: Annexin V/beta5 integrin interactions regulate apoptosis of growth plate chondrocytes.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
annexin A5
Names
VAC-alpha
anchorin CII
annexin V
annexin-5
calphobindin I
endonexin II
lipocortin V
placental anticoagulant protein I
thromboplastin inhibitor
vascular anticoagulant-alpha

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031538.2 → NP_001026709.1  annexin A5

    See identical proteins and their annotated locations for NP_001026709.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000074
    UniProtKB/Swiss-Prot
    P17153
    UniProtKB/TrEMBL
    A0A8V0XMH5
    Conserved Domains (1) summary
    pfam00191
    Location:250 → 315
    Annexin

  2. NM_001397309.1 → NP_001384238.1  annexin A5

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000074
    UniProtKB/Swiss-Prot
    P17153
    UniProtKB/TrEMBL
    A0A8V0XMH5
    Conserved Domains (1) summary
    pfam00191
    Location:250 → 315
    Annexin

  3. NM_001397310.1 → NP_001384239.1  annexin A5

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000074
    UniProtKB/Swiss-Prot
    P17153
    UniProtKB/TrEMBL
    A0A8V0XMH5
    Conserved Domains (1) summary
    pfam00191
    Location:250 → 315
    Annexin

  4. NM_001397311.1 → NP_001384240.1  annexin A5

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000074
    UniProtKB/Swiss-Prot
    P17153
    UniProtKB/TrEMBL
    A0A8V0XMH5
    Conserved Domains (1) summary
    pfam00191
    Location:250 → 315
    Annexin

  5. NM_001397312.1 → NP_001384241.1  annexin A5

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000074
    UniProtKB/Swiss-Prot
    P17153
    UniProtKB/TrEMBL
    A0A8V0XMH5
    Conserved Domains (1) summary
    pfam00191
    Location:250 → 315
    Annexin

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    53469183..53512313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046940311.1 → XP_046796267.1  annexin A5 isoform X1

    UniProtKB/Swiss-Prot
    P17153
    UniProtKB/TrEMBL
    A0A8V0XMH5
    Related
    ENSGALP00010007026.1, ENSGALT00010012462.1

  2. XM_046940312.1 → XP_046796268.1  annexin A5 isoform X1

    UniProtKB/Swiss-Prot
    P17153
    UniProtKB/TrEMBL
    A0A8V0XMH5

  3. XM_046940313.1 → XP_046796269.1  annexin A5 isoform X1

    UniProtKB/Swiss-Prot
    P17153
    UniProtKB/TrEMBL
    A0A8V0XMH5
    Related
    ENSGALP00010007025.1, ENSGALT00010012461.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    53471484..53515093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046916524.1 → XP_046772480.1  annexin A5 isoform X1

    UniProtKB/Swiss-Prot
    P17153
    UniProtKB/TrEMBL
    A0A8V0XMH5

  2. XM_046916525.1 → XP_046772481.1  annexin A5 isoform X1

    UniProtKB/Swiss-Prot
    P17153
    UniProtKB/TrEMBL
    A0A8V0XMH5

  3. XM_046916526.1 → XP_046772482.1  annexin A5 isoform X1

    UniProtKB/Swiss-Prot
    P17153
    UniProtKB/TrEMBL
    A0A8V0XMH5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17153.2 GenPept UniProtKB/Swiss-Prot:P17153

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