GatB Glutamyl-tRNA amidotransferase, subunit B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GatBprovided by FlyBase
Official Full Name: Glutamyl-tRNA amidotransferase, subunit Bprovided by FlyBase
Primary source: FLYBASE:FBgn0039153
Locus tag: Dmel_CG5463
See related: AllianceGenome:FB:FBgn0039153
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5463; Dmel\CG5463
Summary: Predicted to enable glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Predicted to be involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Predicted to be part of glutamyl-tRNA(Gln) amidotransferase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 41. Orthologous to human GATB (glutamyl-tRNA amidotransferase subunit B). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.46	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24128049..24130255, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19953771..19955977, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Homologs of the GatB gene: The GatB gene is conserved in human, chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, A.thaliana, rice, and frog.
Orthologs

Function	Evidence Code	Pubs
enables carbon-nitrogen ligase activity, with glutamine as amido-N-donor	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutaminyl-tRNAGln biosynthesis via transamidation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in glutaminyl-tRNAGln biosynthesis via transamidation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
part_of glutamyl-tRNA(Gln) amidotransferase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

NP_651217.2

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The following sections contain reference sequences that belong to a specific genome build. Explain