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Hsp68 Heat shock protein 68 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42852, updated on 21-Oct-2020

Summary

Official Symbol
Hsp68provided by FlyBase
Official Full Name
Heat shock protein 68provided by FlyBase
Primary source
FLYBASE:FBgn0001230
Locus tag
Dmel_CG5436
Gene type
protein coding
RNA name
heat shock protein 68
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
68; CG5436; Dmel\CG5436; DmHsp68; Hsp-68; hsp68; HSP68; HSP68_DROME

Genomic context

See Hsp68 in Genome Data Viewer
Location:
95D11-95D11; 3-82 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24055080..24057310, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19880802..19883032, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44097 Neighboring gene Autophagy-related 6 Neighboring gene Phosphatidylserine decarboxylase Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes 1 Neighboring gene eukaryotic translation initiation factor 4E homologous protein Neighboring gene Syntaxin 1A

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the Hsp68 gene: The Hsp68 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, S.cerevisiae, K.lactis, E.gossypii, A.thaliana, and frog.
  • Orthologs

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding involved in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cellular response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
heat shock protein 68
Names
CG5436-PA
Hsp 68
Hsp68-PA
NP_524474.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24055080..24057310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079750.4NP_524474.1  heat shock protein 68 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524474.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O97125
    Related
    FBpp0083974, FBtr0084589
    Conserved Domains (2) summary
    cd10233
    Location:3379
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:2635
    PTZ00009; heat shock 70 kDa protein; Provisional
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