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LGR5 leucine rich repeat containing G protein-coupled receptor 5 [ Gallus gallus (chicken) ]

Gene ID: 427867, updated on 3-Dec-2024
Symbol
LGR5provided by CGNC
Full Name
leucine rich repeat containing G protein-coupled receptor 5provided by CGNC
Primary source
CGNC:7727
See related
Ensembl:ENSGALG00010012004
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
GPR49
Orthologs
human mouse all
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See LGR5 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (36359750..36445717)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (36706025..36793541)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene tetraspanin 8 Neighboring gene uncharacterized LOC101747919 Neighboring gene uncharacterized LOC124417663 Neighboring gene zinc finger C3H1-type containing Neighboring gene transmembrane protein 19

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of cells expressing OLFM4 and LGR5 mRNA by in situ hybridization in the yolk sac and small intestine of embryonic and early post-hatch chicks. Zhang H, et al. Poult Sci, 2018 Feb 1. PMID 29155957
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In the yolk sac, cells expressing only LGR5 and not OLFM4 mRNA were localized to the vascular endothelial cells lining the blood vessels. In the small intestine, cells in the intestinal crypt expressed both LGR5 and OLFM4 mRNA.
    Title: Identification of cells expressing OLFM4 and LGR5 mRNA by in situ hybridization in the yolk sac and small intestine of embryonic and early post-hatch chicks.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein-hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
leucine-rich repeat-containing G-protein coupled receptor 5
Names
G protein-coupled receptor 49

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    36359750..36445717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_425441.7 → XP_425441.3  leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YKE5, E1C2F8
    Related
    ENSGALP00010016539.1, ENSGALT00010028749.1
    Conserved Domains (4) summary
    smart00013
    Location:35 → 71
    LRRNT; Leucine rich repeat N-terminal domain
    PLN00113
    Location:72 → 453
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:69 → 92
    LRR_RI; leucine-rich repeat [structural motif]
    cd15363
    Location:559 → 832
    7tmA_LGR5; leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_040669680.2 → XP_040525614.1  leucine-rich repeat-containing G-protein coupled receptor 5 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YKE5
    Conserved Domains (4) summary
    smart00013
    Location:35 → 71
    LRRNT; Leucine rich repeat N-terminal domain
    PLN00113
    Location:72 → 430
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:69 → 92
    LRR_RI; leucine-rich repeat [structural motif]
    cd15363
    Location:536 → 809
    7tmA_LGR5; leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_046912467.1 → XP_046768423.1  leucine-rich repeat-containing G-protein coupled receptor 5 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YKE5

  4. XM_040669689.2 → XP_040525623.1  leucine-rich repeat-containing G-protein coupled receptor 5 isoform X4

    Conserved Domains (3) summary
    PLN00113
    Location:16 → 347
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:27 → 50
    LRR_RI; leucine-rich repeat [structural motif]
    cd15363
    Location:421 → 694
    7tmA_LGR5; leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    36706025..36793541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040662213.2 → XP_040518147.1  leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YKE5, E1C2F8
    Conserved Domains (4) summary
    smart00013
    Location:35 → 71
    LRRNT; Leucine rich repeat N-terminal domain
    PLN00113
    Location:72 → 453
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:69 → 92
    LRR_RI; leucine-rich repeat [structural motif]
    cd15363
    Location:559 → 832
    7tmA_LGR5; leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_040662214.2 → XP_040518148.1  leucine-rich repeat-containing G-protein coupled receptor 5 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YKE5
    Conserved Domains (4) summary
    smart00013
    Location:35 → 71
    LRRNT; Leucine rich repeat N-terminal domain
    PLN00113
    Location:72 → 430
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:69 → 92
    LRR_RI; leucine-rich repeat [structural motif]
    cd15363
    Location:536 → 809
    7tmA_LGR5; leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_046909876.1 → XP_046765832.1  leucine-rich repeat-containing G-protein coupled receptor 5 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YKE5

  4. XM_040662215.2 → XP_040518149.1  leucine-rich repeat-containing G-protein coupled receptor 5 isoform X4

    Conserved Domains (3) summary
    PLN00113
    Location:16 → 347
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:27 → 50
    LRR_RI; leucine-rich repeat [structural motif]
    cd15363
    Location:421 → 694
    7tmA_LGR5; leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version

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