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GLP2R glucagon-like peptide 2 receptor [ Gallus gallus (chicken) ]

Gene ID: 427787, updated on 5-Sep-2025
Official Symbol
GLP2Rprovided by CGNC
Official Full Name
glucagon-like peptide 2 receptorprovided by CGNC
Primary source
CGNC:206
See related
Ensembl:ENSGALG00010029195
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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See GLP2R in Genome Data Viewer
Location:
chromosome: 18
Exon count:
16
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 18 NC_052549.1 (773464..817181)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 18 NC_052590.1 (343505..387224)

Chromosome 18 - NC_052549.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112530021 Neighboring gene uncharacterized LOC121107149 Neighboring gene dehydrogenase/reductase (SDR family) member 7C Neighboring gene GSG1 like 2 Neighboring gene growth arrest specific 7 Neighboring gene uncharacterized LOC107054722 Neighboring gene myosin, heavy chain 13, skeletal muscle

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Intracerebroventricular administration of chicken glucagon-like peptide-2 potently suppresses food intake in chicks. Honda K, et al. Anim Sci J, 2015 Mar. PMID 25410738
  2. Characterization of glucagon-like peptide 2 receptor (GLP2R) gene in chickens: functional analysis, tissue distribution, and developmental expression profile of GLP2R in embryonic intestine. Mo C, et al. Domest Anim Endocrinol, 2014 Jul. PMID 24906922
  3. Expression of proglucagon and proglucagon-derived peptide hormone receptor genes in the chicken. Richards MP, et al. Gen Comp Endocrinol, 2008 Apr 1. PMID 18299131
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GLP-2 functions as a potent anorexigenic peptide in the brain.
    Title: Intracerebroventricular administration of chicken glucagon-like peptide-2 potently suppresses food intake in chicks.
  2. These findings not only establish a molecular basis to explore the physiological roles of GLP2 in birds, but they also provide comparative insights into the roles of GLP2R and its ligand in embryonic intestine development in vertebrates.
    Title: Characterization of glucagon-like peptide 2 receptor (GLP2R) gene in chickens: functional analysis, tissue distribution, and developmental expression profile of GLP2R in embryonic intestine.
  3. GLP-2 receptor genes were highly expressed in the gastrointestinal tract, brain, pancreas and abdominal fat
    Title: Expression of proglucagon and proglucagon-derived peptide hormone receptor genes in the chicken.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables glucagon receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
glucagon-like peptide 2 receptor

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163248.1 → NP_001156720.1  glucagon-like peptide 2 receptor precursor

    See identical proteins and their annotated locations for NP_001156720.1

    Status: PROVISIONAL

    Source sequence(s)
    FJ899744
    UniProtKB/TrEMBL
    A0A8V1AMH8, C4P7J2
    Related
    ENSGALP00010043249.1, ENSGALT00010070558.1
    Conserved Domains (2) summary
    pfam00002
    Location:181 → 407
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:70 → 133
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052549.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    773464..817181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040649525.2 → XP_040505459.1  glucagon-like peptide 2 receptor isoform X2

    UniProtKB/TrEMBL
    A0A8V1AMH8
    Conserved Domains (2) summary
    smart00008
    Location:54 → 123
    HormR; Domain present in hormone receptors
    cd15266
    Location:146 → 416
    7tmB1_GLP2R; glucagon-like peptide-2 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

  2. XM_040649524.2 → XP_040505458.1  glucagon-like peptide 2 receptor isoform X1

    UniProtKB/TrEMBL
    A0A8V1AMH8
    Conserved Domains (2) summary
    smart00008
    Location:66 → 135
    HormR; Domain present in hormone receptors
    cd15266
    Location:158 → 428
    7tmB1_GLP2R; glucagon-like peptide-2 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

  3. XM_040649526.2 → XP_040505460.1  glucagon-like peptide 2 receptor isoform X3

    UniProtKB/TrEMBL
    A0A8V1AGK3
    Related
    ENSGALP00010043248.1, ENSGALT00010070557.1
    Conserved Domains (2) summary
    smart00008
    Location:66 → 135
    HormR; Domain present in hormone receptors
    cd15266
    Location:158 → 428
    7tmB1_GLP2R; glucagon-like peptide-2 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

  4. XM_040649527.2 → XP_040505461.1  glucagon-like peptide 2 receptor isoform X4

    UniProtKB/TrEMBL
    A0A8V1AGK3
    Conserved Domains (3) summary
    smart00008
    Location:66 → 135
    HormR; Domain present in hormone receptors
    cd14964
    Location:185 → 207
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:158 → 419
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052590.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    343505..387224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046929485.1 → XP_046785441.1  glucagon-like peptide 2 receptor isoform X2

    UniProtKB/TrEMBL
    A0A8V1AMH8

  2. XM_046929484.1 → XP_046785440.1  glucagon-like peptide 2 receptor isoform X1

    UniProtKB/TrEMBL
    A0A8V1AMH8

  3. XM_046929486.1 → XP_046785442.1  glucagon-like peptide 2 receptor isoform X3

    UniProtKB/TrEMBL
    A0A8V1AGK3

  4. XM_046929487.1 → XP_046785443.1  glucagon-like peptide 2 receptor isoform X4

    UniProtKB/TrEMBL
    A0A8V1AGK3
Nucleotide Protein
Heading Accession and Version

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