GPX3 glutathione peroxidase 3 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: GPX3provided by CGNC
Official Full Name: glutathione peroxidase 3provided by CGNC
Primary source: CGNC:53151
See related: Ensembl:ENSGALG00010016480
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Aug 2016]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	13	NC_052544.1 (12661488..12663434, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	13	NC_052585.1 (12675277..12677223, complement)

Chromosome 13 - NC_052544.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Selenoprotein Gpx3 knockdown induces myocardial damage through Ca(2+) leaks in chickens.
Title: Selenoprotein Gpx3 knockdown induces myocardial damage through Ca(2+) leaks in chickens.
MiR-1696/GPx3 axis is involved in oxidative stress mediated neutrophil extracellular traps inhibition in chicken neutrophils.
Title: MiR-1696/GPx3 axis is involved in oxidative stress mediated neutrophil extracellular traps inhibition in chicken neutrophils.
we conclude that the apoptotic and autophagic response machineries share antagonistic function in Gpx3 knockdown cardiomyocytes
Title: Effect of Gpx3 gene silencing by siRNA on apoptosis and autophagy in chicken cardiomyocytes.
Dietary low Se downregulated the mRNA expressions of Gpx1-4, Txnrd3, Sepn1, Selw, Sepx1, Selh, and SEPSECS.
Title: Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: glutathione peroxidase 3

Names: glutathione peroxidase 3 (plasma)

NP_001156704.1

EC 1.11.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163232.3 → NP_001156704.1 glutathione peroxidase 3 precursor

Status: REVIEWED

Source sequence(s)

JAENSK010000256

UniProtKB/TrEMBL

A0A8V0YPR6

Related

ENSGALP00010023002.1, ENSGALT00010039755.1

Conserved Domains (1) summary

cd00340
Location:37 → 209

GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

12661488..12663434 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

12675277..12677223 complement

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GenBank, FASTA, Sequence Viewer (Graphics)