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DNApol-epsilon255 DNA polymerase epsilon 255kD subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42758, updated on 27-Feb-2020

Summary

Official Symbol
DNApol-epsilon255provided by FlyBase
Official Full Name
DNA polymerase epsilon 255kD subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0264326
Locus tag
Dmel_CG6768
Gene type
protein coding
RNA name
DNA polymerase epsilon 255kD subunit
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6768; BAB17608; CG6768; Dmel\CG6768; DNA pol epsilon; DNApol-epsilon; dpolepsilon; dpolepsilon255; dpolepsilonp255; l(3)pl10; l(3)pl10R; pl[10]; pol-epsilon; Polepsilon; Polepsilon255

Genomic context

See DNApol-epsilon255 in Genome Data Viewer
Location:
94E13-94E13; 3-78 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23348128..23355163)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19173850..19180885)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene big bubble 8 Neighboring gene pointed Neighboring gene long non-coding RNA:CR46090 Neighboring gene ATP synthase, coupling factor 6 Neighboring gene Secretory 13

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the DNApol-epsilon255 gene: The DNApol-epsilon255 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
3'-5'-exodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA 3'-5' exodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA replication proofreading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication proofreading IDA
Inferred from Direct Assay
more info
PubMed 
DNA synthesis involved in DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
DNA-dependent DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
base-excision repair, gap-filling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endomitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleotide-excision repair, DNA gap filling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epsilon DNA polymerase complex IPI
Inferred from Physical Interaction
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA polymerase epsilon 255kD subunit
Names
CG6768-PA
DNA polymerase epsilon
DNApol-epsilon
DNApol-epsilon255-PA
DNApolymarase E
lethal (3) pl10
NP_524462.2

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23348128..23355163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079738.3NP_524462.2  DNA polymerase epsilon 255kD subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524462.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VCN1
    Related
    FBpp0083800, FBtr0084408
    Conserved Domains (5) summary
    cd05779
    Location:266469
    DNA_polB_epsilon_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
    cd05535
    Location:5291154
    POLBc_epsilon; DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed ...
    smart00486
    Location:265868
    POLBc; DNA polymerase type-B family
    pfam03104
    Location:84425
    DNA_pol_B_exo1; DNA polymerase family B, exonuclease domain
    pfam08490
    Location:15311930
    DUF1744; Domain of unknown function (DUF1744)
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