MC1R melanocortin 1 receptor [Gallus gallus (chicken)] - Gene

Summary

Symbol: MC1Rprovided by CGNC
Full Name: melanocortin 1 receptorprovided by CGNC
Primary source: CGNC:53131
See related: Ensembl:ENSGALG00010009790
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	11	NC_052542.1 (18487539..18488982)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	11	NC_052583.1 (18835523..18836954)

Chromosome 11 - NC_052542.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data clearly show a new and hitherto unsuspected role for MC1R in noncutaneous solid tissues before birth.
Title: Widespread dynamic and pleiotropic expression of the melanocortin-1-receptor (MC1R) system is conserved across chick, mouse and human embryonic development.
The ratio of the black and yellow phenotypes in the F1 offspring of the Chinese commercial line LA self-mating cross (LA x LA) is about 3:1 and in the F1 offspring of a test-cross with the yellow Line B (LB; Fig. 1b), the ratio is about 1:1, indicating that black is a dominant monogenic trait and that LA birds carry a heterozygous genotype.
Title: A new dominant haplotype of MC1R gene in Chinese black plumage chicken.
Exonic variants within the melanocortin 1 receptor (MC1R) gene are useful in distinguishing Black Silky, White Leghorn and Golden duckwing Araucana chicken.
Title: Detection of exonic variants within the melanocortin 1 receptor (MC1R) gene in Black Silky, White Leghorn and Golden duckwing Araucana chicken.
There is a significant correlation between MC1R polymorphism and the presence of different alleles at the E locus. All but one of the populations carrying the E*E or E*R alleles had the G274A polymorphism.
Title: Association between polymorphism in the melanocortin 1 receptor gene and E locus plumage color phenotype.
The results indicate that there is abundant polymorphism in the MC1R gene, especially in Hebei chicken, which was associated with its rich plumage colour diversity.
Title: Genetic variation of chicken MC1R gene in different plumage colour populations.
The co-segregation of plumage coloration and sequence polymorphism in TYR and MC1R genes were investigated using an intercross between black and white plumage color types of the Dongxiang blue-shelled chicken.
Title: Developmental phenotypic-genotypic associations of tyrosinase and melanocortin 1 receptor genes with changing profiles in chicken plumage pigmentation.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables melanocyte-stimulating hormone receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: melanocyte-stimulating hormone receptor

Names: MC1-R; MSH-R; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); melanocortin receptor 1; mutant melanocortin 1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.