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unk unkempt [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42738, updated on 5-Jan-2022

Summary

Official Symbol
unkprovided by FlyBase
Official Full Name
unkemptprovided by FlyBase
Primary source
FLYBASE:FBgn0004395
Locus tag
Dmel_CG4620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4620; Dmel\CG4620
Summary
Predicted to enable zinc ion binding activity. Involved in several processes, including generation of neurons; imaginal disc-derived wing morphogenesis; and sensory organ development. Located in cytoplasm. Is expressed in several structures, including adult brain cell body rind; eye disc; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including UNK (unk zinc finger). [provided by Alliance of Genome Resources, Nov 2021]
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Genomic context

See unk in Genome Data Viewer
Location:
94E1-94E2; 3-78 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23149653..23157862, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18975375..18983584, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hedgehog Neighboring gene Vacuolar H[+] ATPase AC39 subunit 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISM
Inferred from Sequence Model
more info
PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in chaeta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
unkempt
Names
CG4620-PA
CG4620-PB
CG4620-PC
CG4620-PD
CG4620-PE
CG4620-PF
CG4620-PG
unk-PA
unk-PB
unk-PC
unk-PD
unk-PE
unk-PF
unk-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23149653..23157862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275931.1NP_001262860.1  unkempt, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262860.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGS7
    Related
    FBpp0307981, FBtr0337052
    Conserved Domains (3) summary
    COG3210
    Location:310475
    FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
    pfam00642
    Location:273299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:553598
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  2. NM_001260326.2NP_001247255.1  unkempt, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247255.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86B79
    UniProtKB/TrEMBL
    A0A0B4K6Y4
    Related
    FBpp0294024, FBtr0305573
    Conserved Domains (3) summary
    COG3210
    Location:309474
    FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
    pfam00642
    Location:273299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:552597
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  3. NM_176545.3NP_788722.1  unkempt, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788722.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86B79
    UniProtKB/TrEMBL
    A0A0B4K6Y4
    Related
    FBpp0083794, FBtr0084402
    Conserved Domains (3) summary
    COG3210
    Location:309474
    FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
    pfam00642
    Location:273299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:552597
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  4. NM_001260324.2NP_001247253.1  unkempt, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247253.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86B79
    UniProtKB/TrEMBL
    A0A0B4K6Y4
    Related
    FBpp0294022, FBtr0305571
    Conserved Domains (3) summary
    COG3210
    Location:309474
    FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
    pfam00642
    Location:273299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:552597
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  5. NM_001260325.2NP_001247254.1  unkempt, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247254.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7D1
    Related
    FBpp0294023, FBtr0305572
    Conserved Domains (3) summary
    COG3210
    Location:311547
    FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
    pfam00642
    Location:273299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:625670
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  6. NM_001316501.1NP_001303430.1  unkempt, isoform G [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GV12
    Related
    FBpp0312602, FBtr0347570
    Conserved Domains (3) summary
    COG3210
    Location:311548
    FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
    pfam00642
    Location:273299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:626671
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  7. NM_176546.3NP_788723.1  unkempt, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788723.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86B79
    UniProtKB/TrEMBL
    A0A0B4K6Y4
    Related
    FBpp0083795, FBtr0084403
    Conserved Domains (3) summary
    COG3210
    Location:309474
    FhaB; Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]
    pfam00642
    Location:273299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:552597
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
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