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hh hedgehog [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42737, updated on 9-May-2019

Summary

Official Symbol
hhprovided by FlyBase
Official Full Name
hedgehogprovided by FlyBase
Primary source
FLYBASE:FBgn0004644
Locus tag
Dmel_CG4637
Gene type
protein coding
RNA name
hedgehog
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0134654.19; anon-WO0182946.19; bar; bar-3; bar3; CG4637; Dmel\CG4637; hg; Hg; Hh; HH; l(3)hh; l(3)neo56; l(3)neo57; Mir; Mrt

Genomic context

Location:
94E1-94E1; 3-78 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23128169..23141906, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18953891..18967628, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Centaurin beta 1A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene unkempt Neighboring gene Vacuolar H[+] ATPase AC39 subunit 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the hh gene: The hh gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, and frog.

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
morphogen activity IDA
Inferred from Direct Assay
more info
PubMed 
morphogen activity TAS
Traceable Author Statement
more info
PubMed 
patched binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
patched binding NAS
Non-traceable Author Statement
more info
PubMed 
patched binding TAS
Traceable Author Statement
more info
PubMed 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
smoothened binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Bolwig's organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
analia development TAS
Traceable Author Statement
more info
PubMed 
anterior commissure morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
anterior head segmentation TAS
Traceable Author Statement
more info
PubMed 
anterior/posterior axis specification, embryo NAS
Non-traceable Author Statement
more info
PubMed 
anterior/posterior lineage restriction, imaginal disc TAS
Traceable Author Statement
more info
PubMed 
cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell signaling involved in cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
compartment pattern specification TAS
Traceable Author Statement
more info
PubMed 
compound eye morphogenesis TAS
Traceable Author Statement
more info
PubMed 
compound eye photoreceptor cell differentiation TAS
Traceable Author Statement
more info
PubMed 
cytoneme assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
developmental pigmentation TAS
Traceable Author Statement
more info
PubMed 
ectoderm development NAS
Non-traceable Author Statement
more info
PubMed 
embryonic pattern specification IEP
Inferred from Expression Pattern
more info
PubMed 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
foregut morphogenesis TAS
Traceable Author Statement
more info
PubMed 
genital disc anterior/posterior pattern formation IEP
Inferred from Expression Pattern
more info
PubMed 
genital disc development IMP
Inferred from Mutant Phenotype
more info
PubMed 
genital disc development TAS
Traceable Author Statement
more info
PubMed 
germ cell attraction TAS
Traceable Author Statement
more info
PubMed 
NOT germ cell migration IDA
Inferred from Direct Assay
more info
PubMed 
germ cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ-line stem cell division TAS
Traceable Author Statement
more info
PubMed 
glial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
gonadal mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development TAS
Traceable Author Statement
more info
PubMed 
heart formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hindgut morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hindgut morphogenesis TAS
Traceable Author Statement
more info
PubMed 
imaginal disc growth TAS
Traceable Author Statement
more info
PubMed 
imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
imaginal disc-derived wing vein specification TAS
Traceable Author Statement
more info
PubMed 
intein-mediated protein splicing IEA
Inferred from Electronic Annotation
more info
 
labial disc development IMP
Inferred from Mutant Phenotype
more info
PubMed 
leg disc morphogenesis TAS
Traceable Author Statement
more info
PubMed 
mesoderm development NAS
Non-traceable Author Statement
more info
PubMed 
morphogenesis of larval imaginal disc epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
mucosal immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovarian follicle cell stalk formation TAS
Traceable Author Statement
more info
PubMed 
pole cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
posterior head segmentation TAS
Traceable Author Statement
more info
PubMed 
progression of morphogenetic furrow involved in compound eye morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
progression of morphogenetic furrow involved in compound eye morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
progression of morphogenetic furrow involved in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
progression of morphogenetic furrow involved in compound eye morphogenesis TAS
Traceable Author Statement
more info
PubMed 
protein autoprocessing IDA
Inferred from Direct Assay
more info
PubMed 
protein autoprocessing IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
segment polarity determination IEP
Inferred from Expression Pattern
more info
PubMed 
segment polarity determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
segment polarity determination TAS
Traceable Author Statement
more info
PubMed 
smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic stem cell division TAS
Traceable Author Statement
more info
PubMed 
spiracle morphogenesis, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
terminal cell fate specification, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
trunk segmentation TAS
Traceable Author Statement
more info
PubMed 
ventral midline development IMP
Inferred from Mutant Phenotype
more info
PubMed 
wing disc anterior/posterior pattern formation TAS
Traceable Author Statement
more info
PubMed 
wing disc pattern formation IDA
Inferred from Direct Assay
more info
PubMed 
wing disc proximal/distal pattern formation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
hedgehog
Names
CG4637-PB
PKC
atypical
bar-on-3
hedghog
hh-PB
mirabile
moonrat
NP_001034065.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23128169..23141906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001038976.1NP_001034065.1  hedgehog [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001034065.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q02936
    Related
    FBpp0099945, FBtr0100506
    Conserved Domains (3) summary
    cd00081
    Location:258400
    Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
    pfam01079
    Location:254465
    Hint; Hint module
    pfam01085
    Location:99243
    HH_signal; Hedgehog amino-terminal signalling domain
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