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IQGAP2 IQ motif containing GTPase activating protein 2 [ Gallus gallus (chicken) ]

Gene ID: 427211, updated on 28-Apr-2026
Official Symbol
IQGAP2provided by CGNC
Official Full Name
IQ motif containing GTPase activating protein 2provided by CGNC
Primary source
CGNC:11128
See related
Ensembl:ENSGALG00010010688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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See IQGAP2 in Genome Data Viewer
Location:
chromosome: Z
Exon count:
38
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (24003163..24119280, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (24003163..24119280, complement)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121108266 Neighboring gene uncharacterized LOC100857549 Neighboring gene coagulation factor II thrombin receptor Neighboring gene coagulation factor II thrombin receptor like 2 Neighboring gene synaptic vesicle glycoprotein 2C Neighboring gene uncharacterized LOC124417522 Neighboring gene POC5 centriolar protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
ras GTPase-activating-like protein IQGAP2
Names
IQ motif containing GTPase activating protein 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277778.2 → NP_001264707.2  ras GTPase-activating-like protein IQGAP2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000089

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    24003163..24119280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015277326.4 → XP_015132812.1  ras GTPase-activating-like protein IQGAP2 isoform X7

    UniProtKB/TrEMBL
    A0A3Q2UGG0
    Conserved Domains (6) summary
    smart00015
    Location:538 → 558
    IQ; Calmodulin-binding motif
    cd05131
    Location:764 → 1122
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:753 → 1080
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00612
    Location:570 → 589
    IQ; IQ calmodulin-binding motif
    pfam03836
    Location:1216 → 1348
    RasGAP_C; RasGAP C-terminus

  2. XM_015277323.4 → XP_015132809.1  ras GTPase-activating-like protein IQGAP2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Y613
    Conserved Domains (6) summary
    smart00015
    Location:688 → 708
    IQ; Calmodulin-binding motif
    cd05131
    Location:914 → 1272
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:903 → 1230
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00612
    Location:720 → 739
    IQ; IQ calmodulin-binding motif
    pfam03836
    Location:1366 → 1498
    RasGAP_C; RasGAP C-terminus

  3. XM_015277321.4 → XP_015132807.1  ras GTPase-activating-like protein IQGAP2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y613
    Related
    ENSGALP00010014395.1, ENSGALT00010025488.1
    Conserved Domains (6) summary
    smart00015
    Location:772 → 792
    IQ; Calmodulin-binding motif
    cd05131
    Location:998 → 1356
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:987 → 1314
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00612
    Location:804 → 823
    IQ; IQ calmodulin-binding motif
    pfam03836
    Location:1450 → 1582
    RasGAP_C; RasGAP C-terminus

  4. XM_015277325.4 → XP_015132811.1  ras GTPase-activating-like protein IQGAP2 isoform X6

    UniProtKB/TrEMBL
    A0A3Q2UGG0, A0A8V0Y1G1
    Related
    ENSGALP00010014407.1, ENSGALT00010025513.1
    Conserved Domains (6) summary
    smart00015
    Location:539 → 559
    IQ; Calmodulin-binding motif
    cd05131
    Location:765 → 1123
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:754 → 1081
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00612
    Location:571 → 590
    IQ; IQ calmodulin-binding motif
    pfam03836
    Location:1217 → 1349
    RasGAP_C; RasGAP C-terminus

  5. XM_015277322.4 → XP_015132808.1  ras GTPase-activating-like protein IQGAP2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y1E5, A0A8V0Y613
    Related
    ENSGALP00010014391.1, ENSGALT00010025475.1
    Conserved Domains (6) summary
    smart00015
    Location:689 → 709
    IQ; Calmodulin-binding motif
    cd05131
    Location:915 → 1273
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:904 → 1231
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00612
    Location:721 → 740
    IQ; IQ calmodulin-binding motif
    pfam03836
    Location:1367 → 1499
    RasGAP_C; RasGAP C-terminus

  6. XM_015277324.4 → XP_015132810.1  ras GTPase-activating-like protein IQGAP2 isoform X5

    UniProtKB/TrEMBL
    A0A3Q2UGG0
    Related
    ENSGALP00010014402.1, ENSGALT00010025501.1
    Conserved Domains (6) summary
    smart00015
    Location:623 → 643
    IQ; Calmodulin-binding motif
    cd05131
    Location:849 → 1207
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:838 → 1165
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00612
    Location:655 → 674
    IQ; IQ calmodulin-binding motif
    pfam03836
    Location:1301 → 1433
    RasGAP_C; RasGAP C-terminus

  7. XM_015277320.4 → XP_015132806.1  ras GTPase-activating-like protein IQGAP2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y613, A0A8V0Y7K9
    Related
    ENSGALP00010014388.1, ENSGALT00010025469.1
    Conserved Domains (6) summary
    smart00015
    Location:773 → 793
    IQ; Calmodulin-binding motif
    cd05131
    Location:999 → 1357
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:988 → 1315
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00612
    Location:805 → 824
    IQ; IQ calmodulin-binding motif
    pfam03836
    Location:1451 → 1583
    RasGAP_C; RasGAP C-terminus

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    24003163..24119280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046935050.1 → XP_046791006.1  ras GTPase-activating-like protein IQGAP2 isoform X7

    UniProtKB/TrEMBL
    A0A3Q2UGG0

  2. XM_046935047.1 → XP_046791003.1  ras GTPase-activating-like protein IQGAP2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Y613

  3. XM_046935045.1 → XP_046791001.1  ras GTPase-activating-like protein IQGAP2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y613

  4. XM_046935049.1 → XP_046791005.1  ras GTPase-activating-like protein IQGAP2 isoform X6

    UniProtKB/TrEMBL
    A0A3Q2UGG0, A0A8V0Y1G1

  5. XM_046935046.1 → XP_046791002.1  ras GTPase-activating-like protein IQGAP2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y1E5, A0A8V0Y613

  6. XM_046935048.1 → XP_046791004.1  ras GTPase-activating-like protein IQGAP2 isoform X5

    UniProtKB/TrEMBL
    A0A3Q2UGG0

  7. XM_046935044.1 → XP_046791000.1  ras GTPase-activating-like protein IQGAP2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y613, A0A8V0Y7K9
Nucleotide Protein Strain
Heading Accession and Version

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