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tHMG1 testis-enriched HMG-box-containing protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42650, updated on 6-Jul-2026
Official Symbol
tHMG1provided by FlyBase
Official Full Name
testis-enriched HMG-box-containing protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0038978
Locus tag
Dmel_CG7045
See related
AllianceGenome:FB:FBgn0038978
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7045; Dmel\CG7045; thmg-1; tHMG-1
Summary
Predicted to enable DNA binding activity, bending. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytoplasm; nucleus; and polytene chromosome interband. Is expressed in male germline cell and testis. [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See tHMG1 in Genome Data Viewer
Location:
94B1-94B1; 3-75 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22491829..22492381)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18317551..18318103)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Prefoldin 5 Neighboring gene uncharacterized protein Neighboring gene Chaperonin containing TCP1 subunit 1 Neighboring gene testis-enriched HMG-box-containing protein 2 Neighboring gene Octopamine beta1 receptor

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The HMG-box-containing proteins tHMG-1 and tHMG-2 interact during the histone-to-protamine transition in Drosophila spermatogenesis. Gärtner SM, et al. Eur J Cell Biol, 2015 Jan. PMID 25464903
  2. High mobility group proteins HMGD and HMGZ interact genetically with the Brahma chromatin remodeling complex in Drosophila. Ragab A, et al. Genetics, 2006 Feb. PMID 16299391, Free PMC Article
  3. Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development. Xia S, et al. PLoS Genet, 2021 Jul. PMID 34242211, Free PMC Article
  4. A haystack in the needle: packaging sperm DNA in insects. Dubruille R, et al. Curr Opin Genet Dev, 2025 Aug. PMID 40627886
  5. A Testis-Specific Chaperone and the Chromatin Remodeler ISWI Mediate Repackaging of the Paternal Genome. Doyen CM, et al. Cell Rep, 2015 Nov 17. PMID 26549447

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in polytene chromosome interband IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
testis-enriched HMG-box-containing protein 1
Names
CG7045-PA
tHMG1-PA
testis-enriched HMG-box-containing protein-1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22491829..22492381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142798.2 → NP_651055.1  testis-enriched HMG-box-containing protein 1

    See identical proteins and their annotated locations for NP_651055.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0PV93, Q9VCZ5
    Related
    FBpp0083651
    Conserved Domains (2) summary
    cd01390
    Location:8 → 74
    HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
    pfam06501
    Location:55 → 116
    Herpes_U55; Human herpesvirus U55 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VCZ5 Q9VCZ5

Gene LinkOut

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