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AP-2mu Adaptor Protein complex 2, mu subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42642, updated on 6-Jul-2026
Official Symbol
AP-2muprovided by FlyBase
Official Full Name
Adaptor Protein complex 2, mu subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0263351
Locus tag
Dmel_CG7057
See related
AllianceGenome:FB:FBgn0263351
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey50; anon-WO0172774.104; AP-50; AP2mu2; AP50; apm4; cg7057; CG7057; Dmel\CG7057; Dmu2; MENE (3R)-D; MENE(3R)-D; mu2; mu2-ada
Summary
Enables clathrin adaptor activity. Involved in endocytosis. Part of AP-2 adaptor complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval garland cell; gastric caecum; and gut section. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 60 with seizures. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See AP-2mu in Genome Data Viewer
Location:
94A15-94A16; 3-74 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22462455..22464603)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18288177..18290325)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Regulatory particle non-ATPase 7 Neighboring gene uncharacterized protein Neighboring gene Phosphatidylethanolamine-binding protein 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Modeling AP2M1 developmental and epileptic encephalopathy in Drosophila. Karge RA, et al. Dis Model Mech, 2025 Nov 1. PMID 41017589, Free PMC Article
  2. Defective expression of the mu3 subunit of the AP-3 adaptor complex in the Drosophila pigmentation mutant carmine. Mullins C, et al. Mol Gen Genet, 1999 Oct. PMID 10589826
  3. The sorting nexin, DSH3PX1, connects the axonal guidance receptor, Dscam, to the actin cytoskeleton. Worby CA, et al. J Biol Chem, 2001 Nov 9. PMID 11546816
  4. RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis. Jullien-Flores V, et al. J Cell Sci, 2000 Aug. PMID 10910768
  5. Dynamin-mediated endocytosis is required for tube closure, cell intercalation, and biased apical expansion during epithelial tubulogenesis in the Drosophila ovary. Peters NC, et al. Dev Biol, 2016 Jan 1. PMID 26542010, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables clathrin-cargo adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin-cargo adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-1 adaptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-2 adaptor complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
adaptor protein complex 2, mu subunit
Names
AP-2mu-PA
AP-2mu-PB
AP-2mu-PC
AP-50
CG7057-PA
CG7057-PB
CG7057-PC
adaptor protein complex 2
clathrin AP-2 complex
mu2 medium chain of adaptin AP2
mu2-adaptin

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22462455..22464603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142792.5 → NP_651049.3  adaptor protein complex 2, mu subunit, isoform B

    See identical proteins and their annotated locations for NP_651049.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62530, Q7K052
    Related
    FBpp0083646
    Conserved Domains (2) summary
    cd09251
    Location:166 → 436
    AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
    cd14836
    Location:1 → 140
    AP2_Mu_N; AP-2 complex subunit mu N-terminal domain

  2. NM_001170215.2 → NP_001163686.1  adaptor protein complex 2, mu subunit, isoform C

    See identical proteins and their annotated locations for NP_001163686.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62530, Q7K052
    Conserved Domains (2) summary
    cd09251
    Location:166 → 436
    AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
    cd14836
    Location:1 → 140
    AP2_Mu_N; AP-2 complex subunit mu N-terminal domain

  3. NM_170015.3 → NP_732744.1  adaptor protein complex 2, mu subunit, isoform A

    See identical proteins and their annotated locations for NP_732744.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62530, Q7K052
    Related
    FBpp0083645
    Conserved Domains (2) summary
    cd09251
    Location:166 → 436
    AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
    cd14836
    Location:1 → 140
    AP2_Mu_N; AP-2 complex subunit mu N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O62530 O62530

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