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PyK Pyruvate kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42620, updated on 14-Nov-2024

Summary

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Official Symbol
PyKprovided by FlyBase
Official Full Name
Pyruvate kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0267385
Locus tag
Dmel_CG7070
See related
AllianceGenome:FB:FBgn0267385
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg7070; CG7070; Dmel\CG7070; l(3)rQ178; l(3)r[Q178]; Pk; PK; PKM; Pyk; PYK
Summary
Enables pyruvate kinase activity. Involved in glucose homeostasis; pyruvate metabolic process; and response to sucrose. Located in P granule and cytosol. Is expressed in several structures, including adult brain; adult head; adult heart; germline cell; and muscle cell. Used to study disease of metabolism. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R) and PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See PyK in Genome Data Viewer
Location:
94A6-94A6; 3-74 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22367536..22372746)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18193258..18198468)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene muted Neighboring gene uncharacterized protein Neighboring gene RNA polymerase III subunit F Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Localization of a dosage sensitive region for pyruvate kinase in Drosophila melanogaster. Rust KJ, et al. J Hered, 1985 Jan-Feb. PMID 3920304
  2. Drosophila germ granules are assembled from protein components through different modes of competing interactions with the multi-domain Tudor protein. Wahiduzzaman, et al. FEBS Lett, 2024 Apr. PMID 38499396
  3. Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction. Schriner SE, et al. PLoS One, 2013. PMID 23704949, Free PMC Article
  4. Mushroom body glycolysis is required for olfactory memory in Drosophila. Wu CL, et al. Neurobiol Learn Mem, 2018 Apr. PMID 29477608
  5. Metabolic Characterization and Consequences of Mitochondrial Pyruvate Carrier Deficiency in Drosophila melanogaster. Simard C, et al. Metabolites, 2020 Sep 6. PMID 32899962, Free PMC Article

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase.
    Title: Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyruvate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pyruvate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in canonical glycolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in pyruvate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyruvate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to sucrose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in P granule IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
pyruvate kinase
Names
CG7070-PA
CG7070-PB
PyK-PA
PyK-PB
lethal (3) rQ178
NP_524448.3
NP_732723.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22367536..22372746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170004.2 → NP_732723.1  pyruvate kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732723.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62619
    Related
    FBpp0083610
    Conserved Domains (2) summary
    cd00288
    Location:25 → 511
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:25 → 508
    pyruv_kin; pyruvate kinase

  2. NM_079724.3 → NP_524448.3  pyruvate kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524448.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C3KGI0, O62619, Q86PE3, Q8MT14, Q9VD24
    Related
    FBpp0083611
    Conserved Domains (2) summary
    cd00288
    Location:46 → 532
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:46 → 529
    pyruv_kin; pyruvate kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O62619.2 O62619

Gene LinkOut

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