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MGST3 microsomal glutathione S-transferase 3 [ Homo sapiens (human) ]

Gene ID: 4259, updated on 11-Jun-2025
Official Symbol
MGST3provided by HGNC
Official Full Name
microsomal glutathione S-transferase 3provided by HGNC
Primary source
HGNC:HGNC:7064
See related
Ensembl:ENSG00000143198 MIM:604564; AllianceGenome:HGNC:7064
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST-3; GST-III
Summary
This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
Expression
Ubiquitous expression in heart (RPKM 114.7), fat (RPKM 75.6) and 24 other tissues See more
Orthologs
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See MGST3 in Genome Data Viewer
Location:
1q24.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (165631234..165656136)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (164977647..165002573)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (165600471..165625373)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene LRRC52 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:165565420-165565627 Neighboring gene ribosomal protein S2 pseudogene 10 Neighboring gene tRNA-Lys (anticodon CTT) 13-1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:165571612-165571772 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:165599392-165599922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2018 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:165619651-165620850 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:165626303-165626469 Neighboring gene aldehyde dehydrogenase 9 family member A1 Neighboring gene ribosomal protein S13 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 27

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
EBI GWAS Catalog

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of microsomal glutathione S-transferase 3 (MGST3) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables leukotriene-C4 synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables leukotriene-C4 synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in arachidonate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
involved_in leukotriene biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukotriene metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in prostanoid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
glutathione S-transferase 3, mitochondrial
Names
LTC4 synthase MGST3
glutathione peroxidase MGST3
microsomal GST-3
microsomal GST-III
microsomal glutathione S-transferase III
NP_004519.1
XP_047276986.1
XP_054192641.1
XP_054192642.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004528.4NP_004519.1  glutathione S-transferase 3, mitochondrial

    See identical proteins and their annotated locations for NP_004519.1

    Status: REVIEWED

    Source sequence(s)
    AI591182, AL356441, AL451074, BC000505
    Consensus CDS
    CCDS1249.1
    UniProtKB/Swiss-Prot
    B2R592, O14880, Q6ICN4
    UniProtKB/TrEMBL
    Q53GB9
    Related
    ENSP00000356864.3, ENST00000367889.8
    Conserved Domains (1) summary
    pfam01124
    Location:11130
    MAPEG; MAPEG family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    165631234..165656136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421030.1XP_047276986.1  glutathione S-transferase 3, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q53GB9, Q5VV89
    Related
    ENSP00000356860.1, ENST00000367885.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    164977647..165002573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336666.1XP_054192641.1  glutathione S-transferase 3, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q53GB9, Q5VV89
  2. XM_054336667.1XP_054192642.1  glutathione S-transferase 3, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q53GB9, Q5VV89