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MGST3 microsomal glutathione S-transferase 3 [ Homo sapiens (human) ]

Gene ID: 4259, updated on 24-Nov-2020

Summary

Official Symbol
MGST3provided by HGNC
Official Full Name
microsomal glutathione S-transferase 3provided by HGNC
Primary source
HGNC:HGNC:7064
See related
Ensembl:ENSG00000143198 MIM:604564
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST-III
Summary
This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
Expression
Ubiquitous expression in heart (RPKM 114.7), fat (RPKM 75.6) and 24 other tissues See more
Orthologs

Genomic context

See MGST3 in Genome Data Viewer
Location:
1q24.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (165631234..165656136)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (165600110..165625373)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene LRRC52 antisense RNA 1 Neighboring gene ribosomal protein S2 pseudogene 10 Neighboring gene tRNA-Lys (anticodon CTT) 13-1 Neighboring gene aldehyde dehydrogenase 9 family member A1 Neighboring gene ribosomal protein S13 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of microsomal glutathione S-transferase 3 (MGST3) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
leukotriene-C4 synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
leukotriene biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
microsomal glutathione S-transferase 3
Names
LTC4 synthase MGST3
glutathione peroxidase MGST3
microsomal GST-3
microsomal GST-III
microsomal glutathione S-transferase III
NP_004519.1
XP_005245231.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004528.4NP_004519.1  microsomal glutathione S-transferase 3

    See identical proteins and their annotated locations for NP_004519.1

    Status: REVIEWED

    Source sequence(s)
    AI591182, AL356441, AL451074, BC000505
    Consensus CDS
    CCDS1249.1
    UniProtKB/Swiss-Prot
    O14880
    UniProtKB/TrEMBL
    A0A024R8Z1
    Related
    ENSP00000356864.3, ENST00000367889.8
    Conserved Domains (1) summary
    pfam01124
    Location:11130
    MAPEG; MAPEG family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    165631234..165656136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245174.3XP_005245231.2  microsomal glutathione S-transferase 3 isoform X1

    See identical proteins and their annotated locations for XP_005245231.2

    UniProtKB/Swiss-Prot
    O14880
    UniProtKB/TrEMBL
    A0A024R8Z1
    Related
    ENSP00000356859.1, ENST00000367884.6
    Conserved Domains (1) summary
    pfam01124
    Location:11130
    MAPEG; MAPEG family
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