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MGST2 microsomal glutathione S-transferase 2 [ Homo sapiens (human) ]

Gene ID: 4258, updated on 3-Oct-2020

Summary

Official Symbol
MGST2provided by HGNC
Official Full Name
microsomal glutathione S-transferase 2provided by HGNC
Primary source
HGNC:HGNC:7063
See related
Ensembl:ENSG00000085871 MIM:601733
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST2; MGST-II
Summary
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in liver (RPKM 15.9), small intestine (RPKM 13.0) and 25 other tissues See more
Orthologs

Genomic context

See MGST2 in Genome Data Viewer
Location:
4q31.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (139665725..139754608)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (140586922..140661899)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377622 Neighboring gene uncharacterized LOC101927490 Neighboring gene RN7SK pseudogene 237 Neighboring gene H3 histone pseudogene 16 Neighboring gene mastermind like transcriptional coactivator 3 Neighboring gene RN7SK pseudogene 253 Neighboring gene uncharacterized LOC105377452

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27438, MGC14097

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 
glutathione binding IDA
Inferred from Direct Assay
more info
PubMed 
glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
leukotriene-C4 synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukotriene-C4 synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
glutathione biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
leukotriene biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukotriene biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
membrane lipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
microsomal glutathione S-transferase 2
Names
glutathione peroxidase MGST2
leukotriene C4 synthase MGST2
microsomal GST-2
microsomal GST-II
microsomal glutathione S-transferase II
NP_001191295.1
NP_001191296.1
NP_001191297.1
NP_002404.1
XP_006714284.1
XP_011530274.1
XP_016863700.1
XP_016863701.1
XP_016863702.1
XP_016863703.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204366.2NP_001191295.1  microsomal glutathione S-transferase 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001191295.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 3' UTR and encodes the same isoform (1), as compared to variant 1.
    Source sequence(s)
    AC108053, AC112236
    Consensus CDS
    CCDS3749.1
    UniProtKB/Swiss-Prot
    Q99735
    Related
    ENSP00000482639.1, ENST00000616265.4
    Conserved Domains (1) summary
    pfam01124
    Location:8111
    MAPEG; MAPEG family
  2. NM_001204367.2NP_001191296.1  microsomal glutathione S-transferase 2 isoform 2

    See identical proteins and their annotated locations for NP_001191296.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' region, which results in a downstream AUG start codon, and has an alternate 3' UTR, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC108053, AC112236
    Related
    ENST00000515137.5
  3. NM_001204368.2NP_001191297.1  microsomal glutathione S-transferase 2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001191297.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 3' region, which results in frame-shift, as compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC108053, AC112236
    Consensus CDS
    CCDS56339.1
    UniProtKB/Swiss-Prot
    Q99735
    Related
    ENSP00000424278.1, ENST00000506797.5
  4. NM_002413.5NP_002404.1  microsomal glutathione S-transferase 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_002404.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is a predominant transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC108053, AC112236
    Consensus CDS
    CCDS3749.1
    UniProtKB/Swiss-Prot
    Q99735
    Related
    ENSP00000265498.1, ENST00000265498.6
    Conserved Domains (1) summary
    pfam01124
    Location:8111
    MAPEG; MAPEG family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    139665725..139754608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008211.2XP_016863700.1  microsomal glutathione S-transferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q99735
    Conserved Domains (1) summary
    pfam01124
    Location:8111
    MAPEG; MAPEG family
  2. XM_017008212.2XP_016863701.1  microsomal glutathione S-transferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q99735
    Related
    ENSP00000423008.1, ENST00000503816.1
    Conserved Domains (1) summary
    pfam01124
    Location:8111
    MAPEG; MAPEG family
  3. XM_017008213.1XP_016863702.1  microsomal glutathione S-transferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q99735
    Conserved Domains (1) summary
    pfam01124
    Location:8111
    MAPEG; MAPEG family
  4. XM_017008214.1XP_016863703.1  microsomal glutathione S-transferase 2 isoform X2

  5. XM_006714221.2XP_006714284.1  microsomal glutathione S-transferase 2 isoform X2

    See identical proteins and their annotated locations for XP_006714284.1

    Conserved Domains (1) summary
    pfam01124
    Location:143
    MAPEG; MAPEG family
  6. XM_011531972.2XP_011530274.1  microsomal glutathione S-transferase 2 isoform X2

    See identical proteins and their annotated locations for XP_011530274.1

    Conserved Domains (1) summary
    pfam01124
    Location:143
    MAPEG; MAPEG family

RNA

  1. XR_001741221.1 RNA Sequence

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