CTSS cathepsin S [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: CTSSprovided by CGNC
Official Full Name: cathepsin Sprovided by CGNC
Primary source: CGNC:494
See related: Ensembl:ENSGALG00010028761
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	25	NC_052556.1 (2545641..2551003, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	25	NC_052597.1 (2681083..2685720, complement)

Chromosome 25 - NC_052556.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cathepsin S

NP_001026516.1

EC 3.4.22.27

XP_015135493.2

EC 3.4.22.27

XP_046788566.1

EC 3.4.22.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031345.2 → NP_001026516.1 cathepsin S precursor

See identical proteins and their annotated locations for NP_001026516.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000353

UniProtKB/TrEMBL

Q5ZMR6

Conserved Domains (2) summary

smart00848
Location:28 → 86

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:113 → 326

Peptidase_C1; Papain family cysteine protease

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052556.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

2545641..2551003 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015280007.3 → XP_015135493.2 cathepsin S isoform X1

UniProtKB/TrEMBL

A0A8V1AJV9

Related

ENSGALP00010042860.1, ENSGALT00010069599.1

Conserved Domains (2) summary

smart00848
Location:101 → 159

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

cd02248
Location:187 → 399

Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...