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InR Insulin-like receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42549, updated on 28-Oct-2021

Summary

Official Symbol
InRprovided by FlyBase
Official Full Name
Insulin-like receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0283499
Locus tag
Dmel_CG18402
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
18402; CG18402; DIHR; DILR; dinr; dInr; dInR; dINR; DInr; DInR; dInsR; dINSR; dir; dIR; DIR; Dir-a; Dir-b; DIRbeta; dIRH; DIRH; Dmel\CG18402; er10; inr; inR; Inr; INR; Inr-alpha; Inr-beta; INS; InsR; insulin/insulin-like growth factor receptor; IR; l(3)05545; l(3)93Dj; l(3)er10; lnR; sprout
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Genomic context

See InR in Genome Data Viewer
Location:
93E4-93E9; 3-72 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21570248..21619321, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17395970..17445043, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene slouch Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43653 Neighboring gene long non-coding RNA:CR44034 Neighboring gene mir-998 stem loop Neighboring gene mir-11 stem loop Neighboring gene E2F transcription factor 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

mobile_element

  • Loc: c21610044-21609899 mobile_element_type = transposon:NOF{}1401

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables insulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables insulin receptor substrate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin receptor substrate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables insulin-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables insulin-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphatidylinositol 3-kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in carbohydrate homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryo development ending in birth or egg hatching IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in embryonic development via the syncytial blastoderm IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in female germ-line stem cell asymmetric division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in female germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in female gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in female mating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germ-band shortening IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in germ-line stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germ-line stem-cell niche homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intestinal stem cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymph gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male germ-line stem cell asymmetric division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of entry into reproductive diapause IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptide hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in open tracheal system development HMP PubMed 
involved_in ovarian follicle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fat cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of organ growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein kinase B signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in primary spermatocyte growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to anoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cocaine IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of insulin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of insulin receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Insulin-like receptor
Names
CG18402-PA
CG18402-PB
CG18402-PC
CG18402-PD
InR-PA
InR-PB
InR-PC
InR-PD
Insulin-receptor
drosophila insulin receptor
insulin
insulin receptor
insulin receptor homolog
insulin receptor homologue
insulin-like receptor
insulin-like receptor tyrosine kinase
insulin/IGF receptor
lethal(3)93Dj
sprout
NP_001138093.1
NP_001138094.1
NP_001138095.1
NP_524436.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21570248..21619321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144621.3NP_001138093.1  Insulin-like receptor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138093.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P09208
    Related
    FBpp0288669, FBtr0290230
    Conserved Domains (6) summary
    cd05032
    Location:13641652
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:12241302
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:545592
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:512645
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:356465
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:13711650
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_079712.6NP_524436.2  Insulin-like receptor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524436.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P09208
    Related
    FBpp0083519, FBtr0084121
    Conserved Domains (6) summary
    cd05032
    Location:13641652
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:12241302
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:545592
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:512645
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:356465
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:13711650
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_001144622.2NP_001138094.1  Insulin-like receptor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138094.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P09208
    Related
    FBpp0288670, FBtr0290231
    Conserved Domains (6) summary
    cd05032
    Location:13641652
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:12241302
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:545592
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:512645
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:356465
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:13711650
    Pkinase_Tyr; Protein tyrosine kinase
  4. NM_001144623.2NP_001138095.1  Insulin-like receptor, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138095.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P09208
    Related
    FBpp0288671, FBtr0290232
    Conserved Domains (6) summary
    cd05032
    Location:13641652
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:12241302
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:545592
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:512645
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:356465
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:13711650
    Pkinase_Tyr; Protein tyrosine kinase
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