Format

Send to:

Choose Destination

slmb supernumerary limbs [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42504, updated on 10-Oct-2019

Summary

Official Symbol
slmbprovided by FlyBase
Official Full Name
supernumerary limbsprovided by FlyBase
Primary source
FLYBASE:FBgn0283468
Locus tag
Dmel_CG3412
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GM02031; betaTrCP; CG3412; crd; Dmel\CG3412; FBXW1; ica; l(3)00295; MENE (3R)-B; MENE(3R)-B; shv; slimb; Slimb; SLIMB; Slimb/beta-TrCP; Slimb/beta-TRCP; Slimb/Beta-TRCP1; Slimb/betaTrCP; Slmb; SLMB; wel

Genomic context

See slmb in Genome Data Viewer
Location:
93B13-93C1; 3-70 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21119252..21127485, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16944974..16953207, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rab11 Neighboring gene peter pan Neighboring gene Bride of doubletime Neighboring gene uncharacterized protein Neighboring gene Odorant-binding protein 93a Neighboring gene Interacts with the C terminus of ELL 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ubiquitin-protein transferase activity ISM
Inferred from Sequence Model
more info
 
contributes_to ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
Inferred from Sequence Model
more info
 
chorion-containing eggshell formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm IPI
Inferred from Physical Interaction
more info
PubMed 
dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of epithelial cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
germarium-derived egg chamber formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
germarium-derived female germ-line cyst encapsulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
germarium-derived female germ-line cyst formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of TOR signaling IPI
Inferred from Physical Interaction
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of glial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of nurse cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
oocyte axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
oocyte localization involved in germarium-derived egg chamber formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovarian follicle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovarian follicle cell stalk formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of centriole replication IDA
Inferred from Direct Assay
more info
PubMed 
regulation of chromosome condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of proteolysis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
SCF ubiquitin ligase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
SCF ubiquitin ligase complex ISM
Inferred from Sequence Model
more info
 

General protein information

Preferred Names
supernumerary limbs
Names
CG3412-PA
CG3412-PB
CG3412-PC
SLIMB
centrosome replication defective
icare
pingiel
shiva
slmb-PA
slmb-PB
slmb-PC
wellman

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21119252..21127485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079706.3NP_524430.1  supernumerary limbs, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524430.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VDE3
    Related
    FBpp0083434, FBtr0084032
    Conserved Domains (5) summary
    COG2319
    Location:192495
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:210488
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12125
    Location:4785
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:89136
    F-box-like; F-box-like
    sd00039
    Location:213248
    7WD40; WD40 repeat [structural motif]
  2. NM_001275873.1NP_001262802.1  supernumerary limbs, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262802.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHK1
    Related
    FBpp0303082, FBtr0330049
    Conserved Domains (5) summary
    COG2319
    Location:192495
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:210488
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12125
    Location:4785
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:89136
    F-box-like; F-box-like
    sd00039
    Location:213248
    7WD40; WD40 repeat [structural motif]
  3. NM_001275872.1NP_001262801.1  supernumerary limbs, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262801.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VDE3
    Related
    FBpp0306059, FBtr0333931
    Conserved Domains (5) summary
    COG2319
    Location:192495
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:210488
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12125
    Location:4785
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:89136
    F-box-like; F-box-like
    sd00039
    Location:213248
    7WD40; WD40 repeat [structural motif]
Support Center