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SCGB2A2 secretoglobin family 2A member 2 [ Homo sapiens (human) ]

Gene ID: 4250, updated on 2-Nov-2024

Summary

Official Symbol
SCGB2A2provided by HGNC
Official Full Name
secretoglobin family 2A member 2provided by HGNC
Primary source
HGNC:HGNC:7050
See related
Ensembl:ENSG00000110484 MIM:605562; AllianceGenome:HGNC:7050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MGB1; UGB2; PSBP1
Summary
Predicted to be involved in androgen receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in esophagus (RPKM 14.0), fat (RPKM 1.6) and 1 other tissue See more
Orthologs
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Genomic context

See SCGB2A2 in Genome Data Viewer
Location:
11q12.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62270158..62273160)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62259408..62262421)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62037630..62040632)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene secretoglobin family 2A member 1 Neighboring gene secretoglobin family 1D member 2 Neighboring gene secretoglobin family 1D member 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62092655-62093156 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:62093977-62094636 Neighboring gene nucleophosmin 1 pseudogene 35

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat upregulates the expression of many proteins, including Mammaglobin, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC71974

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in androgen receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
mammaglobin-A
Names
mammaglobin 1
prostatic steroid binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002411.4NP_002402.1  mammaglobin-A precursor

    See identical proteins and their annotated locations for NP_002402.1

    Status: VALIDATED

    Source sequence(s)
    BG207094, U33147
    Consensus CDS
    CCDS8018.1
    UniProtKB/Swiss-Prot
    A1A522, Q13296, Q86WH8
    Related
    ENSP00000227918.2, ENST00000227918.3
    Conserved Domains (1) summary
    pfam01099
    Location:2290
    Uteroglobin; Uteroglobin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    62270158..62273160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274005.4XP_005274062.3  mammaglobin-A isoform X1

    UniProtKB/TrEMBL
    Q6NX70
    Related
    ENSP00000431997.1, ENST00000525380.1
    Conserved Domains (1) summary
    pfam01099
    Location:2289
    Uteroglobin; Uteroglobin family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    62259408..62262421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368828.1XP_054224803.1  mammaglobin-A isoform X1

    UniProtKB/TrEMBL
    Q6NX70