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ORF1 nonstructural polyprotein [ Norovirus GV ]

Gene ID: 4246735, updated on 6-Jun-2024
Gene symbol
ORF1
Gene description
nonstructural polyprotein
Locus tag
NoVGV_gp1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Norovirus GV (isolate: Mu/NoV/GV/MNV1/2002/USA)
Lineage
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; Caliciviridae; Norovirus
Old locus tag
MNV1_gp1
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Location:
clone: CW1
Sequence:
NC_008311.1 (6..5069)

NC_008311.1Genomic Context describing neighboring genes Neighboring gene VP1 Neighboring gene VF1 Neighboring gene VP2

Genomic Sequence:
NC_008311.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal structures of murine norovirus-1 RNA-dependent RNA polymerase in complex with 2-thiouridine or ribavirin. Alam I, et al. Virology, 2012 May 10. PMID 22341781
  2. Crystal structures of murine norovirus-1 RNA-dependent RNA polymerase. Lee JH, et al. J Gen Virol, 2011 Jul. PMID 21471315
  3. Norovirus regulation of the innate immune response and apoptosis occurs via the product of the alternative open reading frame 4. McFadden N, et al. PLoS Pathog, 2011 Dec. PMID 22174679, Free PMC Article
  4. Cleavage map and proteolytic processing of the murine norovirus nonstructural polyprotein in infected cells. Sosnovtsev SV, et al. J Virol, 2006 Aug. PMID 16873239, Free PMC Article
  5. Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages. Wobus CE, et al. PLoS Biol, 2004 Dec. PMID 15562321, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 2-thiouridine or ribavirin binding to MNV-1 RdRp inhibit virus replication in RAW 264.7 cells.
    Title: Crystal structures of murine norovirus-1 RNA-dependent RNA polymerase in complex with 2-thiouridine or ribavirin.
  2. RdRp exists predominantly as a monomer in solution, in equilibrium with a smaller population of dimers, trimers and hexamers.
    Title: Crystal structures of murine norovirus-1 RNA-dependent RNA polymerase.
Submit: New GeneRIF Correction
Preferred Names
nonstructural polyprotein
Names
p48
RdRp
NTPase
p22
VPg
Pro
YP_720001.1
  • ORF1; encodes helicase, protease, and polymerase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_008311.1 Reference assembly

    Range
    6..5069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_720001.1 nonstructural polyprotein [Norovirus GV]

    See identical proteins and their annotated locations for YP_720001.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q2V8W5, Q80J95, S4V9Y7
    UniProtKB/TrEMBL
    A7U6A2
    Conserved Domains (4) summary
    pfam05416
    Location:650 → 1163
    Peptidase_C37; Southampton virus-type processing peptidase
    pfam00910
    Location:500 → 602
    RNA_helicase; RNA helicase
    pfam08405
    Location:132 → 484
    Calici_PP_N; Viral polyprotein N-terminal
    cl02808
    Location:1201 → 1666
    RT_like; RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, ...

  2. YP_724455.1 p48

    Conserved Domains (1) summary
    pfam08405
    Location:132 → 341
    Calici_PP_N; Viral polyprotein N-terminal

  3. YP_724456.1 RdRp

    Conserved Domains (1) summary
    cl02808
    Location:24 → 489
    RT_like; RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, ...

  4. YP_724457.1 NTPase

    Conserved Domains (3) summary
    pfam05416
    Location:309 → 364
    Peptidase_C37; Southampton virus-type processing peptidase
    pfam00910
    Location:159 → 261
    RNA_helicase; RNA helicase
    pfam08405
    Location:1 → 143
    Calici_PP_N; Viral polyprotein N-terminal

  5. YP_724458.1 p22

    Conserved Domains (1) summary
    pfam05416
    Location:1 → 162
    Peptidase_C37; Southampton virus-type processing peptidase

  6. YP_724459.1 VPg

    Conserved Domains (1) summary
    pfam05416
    Location:14 → 124
    Peptidase_C37; Southampton virus-type processing peptidase

  7. YP_724460.1 Pro

    Conserved Domains (1) summary
    pfam05416
    Location:1 → 169
    Peptidase_C37; Southampton virus-type processing peptidase
Protein Accession Links
GenPept Link UniProtKB Link
ABB90153.1

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