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Synd Syndapin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42467, updated on 31-Mar-2026
Official Symbol
Syndprovided by FlyBase
Official Full Name
Syndapinprovided by FlyBase
Primary source
FLYBASE:FBgn0053094
Locus tag
Dmel_CG33094
See related
AllianceGenome:FB:FBgn0053094
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15694; CG33094; D-Synd; Dmel\CG33094; synd
Summary
Enables lipid binding activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; positive regulation of synaptic assembly at neuromuscular junction; and protein localization to rhabdomere. Located in several cellular components, including cleavage furrow; rhabdomere microvillus; and subsynaptic reticulum. Is expressed in adult head; larval nervous system; larval ventral nerve cord; neuromuscular junction; and organism. Orthologous to several human genes including PACSIN1 (protein kinase C and casein kinase substrate in neurons 1) and PACSIN2 (protein kinase C and casein kinase substrate in neurons 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See Synd in Genome Data Viewer
Location:
93A1-93A2; 3-69 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20832799..20840118)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16658521..16665840)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44047 Neighboring gene Adenylosuccinate synthetase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Syndapin promotes pseudocleavage furrow formation by actin organization in the syncytial Drosophila embryo. Sherlekar A, et al. Mol Biol Cell, 2016 Jul 1. PMID 27146115, Free PMC Article
  2. Distinct Bin/Amphiphysin/Rvs (BAR) family proteins may assemble on the same tubule to regulate membrane organization in vivo. Mallik B, et al. Heliyon, 2024 Jul 15. PMID 39040266, Free PMC Article
  3. RNAi Screen in Tribolium Reveals Involvement of F-BAR Proteins in Myoblast Fusion and Visceral Muscle Morphogenesis in Insects. Schultheis D, et al. G3 (Bethesda), 2019 Apr 9. PMID 30733382, Free PMC Article
  4. Drosophila Nedd4-long reduces Amphiphysin levels in muscles and leads to impaired T-tubule formation. Safi F, et al. Mol Biol Cell, 2016 Mar 15. PMID 26823013, Free PMC Article
  5. Syndapin is dispensable for synaptic vesicle endocytosis at the Drosophila larval neuromuscular junction. Kumar V, et al. Mol Cell Neurosci, 2009 Feb. PMID 19059483, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. F-BAR domain protein Syndapin regulates actomyosin dynamics during apical cap remodeling in syncytial Drosophila embryos.
    Title: F-BAR domain protein Syndapin regulates actomyosin dynamics during apical cap remodeling in syncytial Drosophila embryos.
  2. Synd constricts the microvillus neck resulting in the segregation of the two apical membranes: stalk and rhabdomere
    Title: Syndapin constricts microvillar necks to form a united rhabdomere in Drosophila photoreceptors.
  3. study reports Syndapin, a protein containing an F-BAR domain, contributes to remodelling of the plasma membrane around the contractile ring for cytokinesis; Syndapin colocalizes with phosphatidylinositol 4,5-bisphosphate at the cleavage furrow, where it directly interacts with a contractile ring component, Anillin
    Title: Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis.
  4. Syndapin overexpression greatly expands postsynaptic membrane system.
    Title: Syndapin promotes formation of a postsynaptic membrane system in Drosophila.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cleavage furrow ingression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in male meiosis cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to rhabdomere IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rhabdomere development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhabdomere membrane biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle assembly involved in male meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rhabdomere IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rhabdomere microvillus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in subsynaptic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
syndapin
Names
CG33094-PB
CG33094-PC
CG33094-PD
Synd-PB
Synd-PC
Synd-PD

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20832799..20840118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275858.1 → NP_001262787.1  syndapin, isoform D

    See identical proteins and their annotated locations for NP_001262787.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH28
    Conserved Domains (2) summary
    cd07655
    Location:17 → 272
    F-BAR_PACSIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins
    cd11843
    Location:441 → 493
    SH3_PACSIN; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins

  2. NM_176520.2 → NP_788697.1  syndapin, isoform B

    See identical proteins and their annotated locations for NP_788697.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZZ4, Q9VDI1
    Related
    FBpp0083373
    Conserved Domains (2) summary
    cd07655
    Location:17 → 272
    F-BAR_PACSIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins
    cd11843
    Location:440 → 492
    SH3_PACSIN; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins

  3. NM_001275857.1 → NP_001262786.1  syndapin, isoform C

    See identical proteins and their annotated locations for NP_001262786.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH28
    Conserved Domains (2) summary
    cd07655
    Location:17 → 272
    F-BAR_PACSIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins
    cd11843
    Location:441 → 493
    SH3_PACSIN; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KH28 A0A0B4KH28
Q9VDI1 Q9VDI1

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